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Method for preparing bupleurum injection

A technology of Bupleurum injection and Bupleurum, applied in the field of traditional Chinese veterinary medicine, can solve the problems that the extraction process needs to be improved, and achieve the effects of saving electric energy, increasing extraction efficiency, and saving costs

Active Publication Date: 2013-01-16
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the extraction process of this method still needs to be improved

Method used

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  • Method for preparing bupleurum injection
  • Method for preparing bupleurum injection
  • Method for preparing bupleurum injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The concrete preparation method of present embodiment Bupleurum injection is as follows:

[0021] (1) Weigh 1000g of Bupleurum bupleuri, chop it and place it in an extraction tank to form a medicinal material layer, add 90g of sodium chloride and 250g of sulfuric acid solution with a pH value of 1, add 10 times the amount of water to submerge the medicinal material layer, and control the temperature at 40°C, soak for 2.5 hours;

[0022] (2) Adjust the working temperature of the extraction tank to 60°C for extraction. The medicinal materials and the solvent move in opposite directions in the leaching container to contact continuously and fully. The concentration temperature is 50°C and the pressure is 0.08MPa. The steam generated by concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 3 hours, and the extract is distilled at 50°C to obtain volatile oil for late...

Embodiment 2

[0025] The concrete preparation method of present embodiment Bupleurum injection is as follows:

[0026] (1) Weigh 1000g of Bupleurum bupleurum, chop it and place it in an extraction tank to form a medicinal material layer, add 50g of sodium chloride and 100g of hydrochloric acid solution with a pH value of 1, add 8 times the amount of water to cover the medicinal material layer, and control the temperature at 50°C, soak for 2.5 hours;

[0027] (2) Adjust the working temperature of the extraction tank to 80°C for extraction. The medicinal materials and the solvent move in opposite directions in the leaching container to contact continuously and fully. The concentration temperature is 70°C and the pressure is 0.09MPa. The steam generated by concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 3 hours, and the extract is distilled at 60°C to obtain volatile oil for lat...

Embodiment 3

[0030] The concrete preparation method of present embodiment Bupleurum injection is as follows:

[0031] (1) Weigh 500g of Bupleurum bupleurum, chop it and place it in an extraction tank to form a medicinal material layer, add 30g of sodium chloride and 50g of sulfuric acid solution with a pH value of 1, add 8 times the amount of water to cover the medicinal material layer, and control the temperature at 45°C, soak for 1.5 hours;

[0032] (2) Adjust the working temperature of the extraction tank to 70°C for extraction. The medicinal materials and the solvent move in opposite directions in the leaching container to contact continuously and fully. The concentration temperature is 60°C and the pressure is 0.08MPa. The steam generated by concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 2 hours, and the extract is distilled at 55°C to obtain volatile oil for later use...

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Abstract

The invention discloses a method for preparing bupleurum injection, and belongs to the technical field of Chinese veterinary medicaments. Preferably, the temperature in the extraction process of the method is controlled at 60 to 80 DEG C, and the distillation temperature is controlled at 50 to 70 DEG C, so that more active ingredients in medicinal materials are preserved, and evaporation loss of the active ingredients and leaching of impurities such as tannin are furthest avoided; the medicinal materials and a solvent move along the opposite directions in a leaching container in the extraction process, so that the medicinal materials are extracted fully; meanwhile, a part of extract is extracted, concentrated under reduced pressure and condensed to form a new solvent for reflux, and the solvent passes through the medicinal material layer from top to bottom, so that the active ingredients in medicinal materials can be fully dissolved; and soluble substances for dissolving the medicinal materials reach the bottom and then are re-extracted for concentration and rectification procedures. The method is high in efficiency of extracting bupleurum volatile oil, the cost can be reduced by 0.3 to 0.5 times, the electrical energy is saved for over 30 percent, the storage procedure and the consumption of the aqueous solvent are reduced by 0.5 to 1 times, the feeding quantity is increased by 30 to 60 percent, and the yield of the volatile oil is improved by over 10 percent.

Description

technical field [0001] The invention relates to a preparation method of injection, in particular to a preparation method of Bupleurum injection, belonging to the technical field of Chinese veterinary medicine. Background technique [0002] Bupleurum is a traditional Chinese medicine and a commonly used Chinese medicine in my country. It is the root of Bupleurum chinese DC. or B. scorzoneri folium Willd. Bupleurum root contains volatile oil (o-methoxyphenol, eugenol, cresol, ethylphenol, thymol, limonene, etc.), saponins (saikosaponin a, b 2 , b 3 , c, d, f, s 1 , t, q-1, v, v-2, 2"-O-acetyl saponin a, 2"-O-acetyl saponin b 2 etc.), flavonoids (rutin, quercetin, isorhamnetin, puerarin, tryptophan, etc.), lignans, coumarins, sterols, polysaccharides, etc., the main components of which are saponins and volatile oils . Bupleurum bupleurum is bitter, pungent, slightly cold, returns to the liver and gallbladder meridians, can relieve exterior fever, soothe the liver and relie...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/08A61P11/00A61P31/16A61P31/04A61P31/14A61P31/22A61P27/02A61K125/00
Inventor 郭玉凡王佳伟杨晶张宁张旭
Owner ZHENGZHOU BARY ANIMAL PHARMA
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