Preparation method of gelatine-free double-layer hollow capsule

A hollow capsule and gelatin technology, which is applied in the directions of capsule delivery, medical preparations with inactive ingredients, and pharmaceutical formulations, can solve problems such as hidden quality and safety problems of hollow capsules, market impact of traditional capsules, etc., to achieve product safety and reliability, improve collapse The effect of solution performance, good mechanical strength

Active Publication Date: 2013-01-23
JIANGSU QINGYUANKANG BIOLOGY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, currently commercially available gelatin hollow capsules, the basic components include gelatin, glycerin and water; gelatin is a kind of protein material obtained by hydrolysis of animal skin and bone; and the "mad cow disease" that has swept across Europe in recent years, It also had an impact on the traditional capsule market. The US FDA believes that gelatin shoul

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 450g of pullulan, 100g of sodium alginate, add 5000mL of deionized water to make a concentration of 9.9%, heat and fully stir to dissolve, place the fully dissolved glue under vacuum for degassing, and In the degassed glue solution constant temperature water bath, it is the first layer of capsule film-forming solution, for subsequent use;

[0019] Weigh 380g of hydroxypropyl methylcellulose and 380g of methylcellulose, add 4000mL of deionized water to make a concentration of 16%, fully stir and dissolve, and place the fully dissolved glue under vacuum for degassing , put the degassed glue solution into a constant temperature water bath whose temperature is maintained at 56° C., to be the second layer of capsule film-forming solution, and set aside;

[0020] Dip the glue once: slowly insert the mold into the first layer of capsule film-forming solution, the speed should not be too fast to prevent air bubbles, the mold stays in the glue solution for about 4 seconds ...

Embodiment 2

[0022] Weigh 450g of pullulan, 150g of sodium alginate, add 4000mL of deionized water to make a concentration of 13%, heat and stir to dissolve, place the fully dissolved glue under vacuum for degassing, and degass the deionized In the glue solution constant temperature water bath after soaking, it is the film-forming solution of the first layer of capsules, and it is set aside;

[0023] Weigh 360 g of hydroxypropyl methylcellulose and 360 g of methylcellulose, add 4000 mL of deionized water to make a concentration of 15%, stir and dissolve, and place the fully dissolved glue under vacuum for degassing , put the defoamed glue solution into a constant temperature water bath whose temperature is maintained at 58° C., to be the second layer of capsule film-forming solution, and set aside;

[0024] One-time glue dipping: slowly insert the mold into the first layer of capsule film-forming solution, the speed should not be too fast to prevent air bubbles, the mold stays in the glue ...

Embodiment 3

[0026] Weigh 450g of pullulan, 50g of sodium alginate, add 6000mL of deionized water to make a concentration of 7.7%, heat and stir to dissolve, place the fully dissolved glue under vacuum for degassing, and degass In the final glue liquid constant temperature water bath, it is the first layer of capsule film-forming liquid, for subsequent use;

[0027] Weigh 410g of hydroxypropyl methylcellulose and 410g of methylcellulose, add 4000mL of deionized water to make a concentration of 17%, stir and dissolve, and place the completely dissolved glue under vacuum for defoaming , put the defoamed glue solution into a constant temperature water bath whose temperature is maintained at 54° C., to be the second layer of capsule film-forming solution, and set aside;

[0028] One-time glue dipping: slowly insert the mold into the first layer of capsule film-forming solution, the speed should not be too fast to prevent air bubbles, the mold stays in the glue solution for about 4 seconds and ...

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Abstract

The invention relates to a preparation method of a gelatine-free double-layer hollow capsule. The preparation method is characterized by comprising the following steps of: by taking microbial polysaccharide gum, algal polysaccharide gum and plant polysaccharide gum as raw materials; and mixing, dissolving the gums, degassing, dipping the gums, drying, dipping the gums again, drying again, shelling, cutting and trimming, so as to prepare the gelatine-free double-layer hollow capsule, wherein the inner layer of the capsule contains pullulan and sodium alginate, and the outer layer of the capsule contains hydroxypropyl methyl cellulose and methylcellulose. With the adoption of the double-layer structure, the disintegration performance of the capsule can be greatly improved, and the good mechanical strength of the whole capsule can be kept. The product can be used for filling various medicines and healthcare foods by taking the microbial polysaccharide gum, the algal polysaccharide gum and the plant polysaccharide gum as the raw materials and avoiding the use of any gelatine ingredient; the product is safe, reliable, and is suitably eaten by Buddhist, Moslems and vegetarian; and the worry of people about eating for gelatine products caused by 'bovine spongiform encephalopathy' is avoided.

Description

technical field [0001] The invention relates to a preparation method of a gelatin-free double-layer hollow capsule, which belongs to the technical field of hard capsule processing. Background technique [0002] At present, conventional hollow capsules are composed of a cap and a body, which are refined from medicinal gelatin and auxiliary materials. They are mainly used to hold solid medicines, such as self-made powders, health products, medicines, etc. , the problem of poor taste has truly realized that good medicine is no longer bitter; hollow capsules are becoming more and more popular. First of all, the shape of capsules is slender and easy to swallow, which is the most popular dosage form for consumers; in addition, capsules can effectively cover up Unpleasant taste and odor of the contents; Capsules come in a variety of sizes, including size 00 extended and size 5 capsules. Capsules can also be printed with words, logos and patterns to present a unique customized appe...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A61K47/38
Inventor 童群义陈金林刘国军陈大伟
Owner JIANGSU QINGYUANKANG BIOLOGY TECH
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