Fluorescence-optical combined tomography system and measuring method

Abstract

The invention discloses a fluorescence-optical combined tomography system and a measuring method. The fluorescence-optical combined tomography system comprises a light source module, a measuring module, a data acquisition and processing module, and a computer control module, wherein the light source module produces exciting light with different wavelengths and couples the exciting light into composite exciting light; the measuring module is used for placing an imaging target body, receiving the composite exciting light, measuring the imaging target body in a layering mode, realizing fully three-dimensional scanning, scattering a photon signal, and converting the photon signal into a pulse electric signal for output; the data acquisition and processing module receives the pulse electric signal, and performs multi-dimensional photon counting measurement; and the computer control module is used for controlling the modules, and acquiring, analyzing and displaying data. According to the system, fluorescence diffuse optical tomography (FDOT) and diffuse optical tomography (DOT) are fused, so that the simultaneous reconstruction of the fluorescence yield and the fluorescence lifetime in the FDOT is realized, a target in an affected region is extracted, and accurate position information is provided for the reconstruction of an absorption coefficient and a scattering coefficient in the DOT in the next step.

Description

technical field [0001] The invention relates to an imaging system, in particular to a fluorescence-optical combined tomographic imaging system. Background technique [0002] Breast cancer is the most common female malignant cancer. According to statistics, the incidence rate accounts for 7% to 10% of all kinds of malignant cancers in the whole body. Diffuse Optical Tomography (DOT), based on the property that 600-1000nm near-infrared light can penetrate thicker tissues, can non-invasively and quantitatively provide the distribution of optical absorption coefficient inside the tissue, so that it can effectively use Hemodynamic information reconstructs the distribution of oxygenated hemoglobin and deoxygenated hemoglobin in the tissue body, which is closely related to the pathological process. Combined with the optical scattering coefficient reflecting the fractal morphology of the tissue, DOT can distinguish benign and malignant tumors and monitor the response of cancerous t...

AI Technical Summary

Problems solved by technology

The above-mentioned strategies have all achieved a certain degree of effect, but their disadvantages are: firstly, it often leads to complex and redundant imaging systems and increased costs; secondly, anatomical imaging methods cannot provide effective data for DOT reconstruction in the early diagnosis of tumor tissue. "Prior" information does not achieve the goal of reducing the morbidity of the problem

However, for existing cancers, especially in the detection of breast cancer, the existing technology does not use the method of FDOT-DOT combined imaging measurement

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