Unlock instant, AI-driven research and patent intelligence for your innovation.

Medicinal composition of cefodizime compound

A technology of cefodizime and its composition, which is applied in the field of cephalosporins and cefodizime compositions, can solve the problems of cefodizime loss and the like, and achieve the effects of improving water solubility, facilitating clinical use, and reducing dosage

Active Publication Date: 2014-05-28
罗诚
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also disclose other by the method that cefodizime changes into cefodizime sodium, no matter which kind of method, it all can have part cefodizime can not change into salt and lose

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition of cefodizime compound
  • Medicinal composition of cefodizime compound
  • Medicinal composition of cefodizime compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 10 g of cefodizime in a mixed solvent of 50 mL of ethanol, dimethylformamide and dichloromethane at a temperature of 30° C., wherein the volume ratio of ethanol, dimethylformamide and dichloromethane is 8 : 2: 1.5, add 300mL of distilled water at 0°C to the solution, then let it stand for 2 hours in an environment at 0°C, a white precipitate appears, filter, wash the filter cake twice with acetone, and dry it in vacuum After 2.5 hours, cefodizime crystals were obtained. Gained cefodizime crystal carries out X-ray powder diffraction experiment, and result is as follows figure 1 shown.

Embodiment 2

[0027] Dissolve 10 g of cefodizime in a mixed solvent of 40 mL of ethanol, dimethylformamide and dichloromethane at a temperature of 30° C., wherein the volume ratio of ethanol, dimethylformamide and dichloromethane is 8 : 1.5: 3, add 300mL of distilled water at -5°C to the solution, then let it stand at 0°C for 1.5 hours, a white precipitate appears, filter, wash the filter cake twice with acetone, and vacuum dry After 2 hours, crystals of cefodizime were obtained. Gained cefodizime crystal carries out X-ray powder diffraction experiment, and result is as follows figure 1 To match.

Embodiment 3

[0029] Dissolve 10 g of cefodizime in a mixed solvent of 60 mL of ethanol, dimethylformamide and dichloromethane at a temperature of 25° C., wherein the volume ratio of ethanol, dimethylformamide and dichloromethane is 8 : 1: 3, add 300mL of distilled water at a temperature of 5°C to the solution, then let it stand for 2 hours in an environment with a temperature of -5°C, a white precipitate appears, filter, wash the filter cake twice with acetone, and dry it in vacuum After 2 hours, crystals of cefodizime were obtained. Gained cefodizime crystal carries out X-ray powder diffraction experiment, and result is as follows figure 1 To match.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A medicinal composition of a cefodizime compound comprises cefodizime crystals and sodium carbonate, wherein the weight percentage of cefodizime crystals and sodium carbonate is 100:8-100:11, a diffraction pattern of an X-ray powder of the cefodizime crystal is shown in figure 1, wherein 2 theta is displayed with the characteristic peaks at 6.58 degrees + / -0.1 degrees, 11.22 degrees+ / -0.1 degrees, 11.51 degrees + / -0.1 degrees, 15.82 degrees+ / -0.1 degrees, 16.52 degrees+ / -0.1 degrees, 17.21 degrees + / -0.1 degrees, 19.49 degrees+ / -0.1 degrees, and 23.04 degrees+ / -0.1 degrees, and the water solubility of the composition is improved; when the composition and the anhydrous sodium carbonate are prepared into sterile powder injection, the dose of the anhydrous sodium carbonate is greatly reduced, and the dissolving speed is fast, namely the composition is completely dissolved in a short time, and the stability is good, so that the medicinal composition of the cefodizime compound is convenient for clinical use.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a cephalosporin drug, more specifically a cefodizime composition. Background technique [0002] Cefodizime was invented by Hoechst, Germany, and it is the world's first third-generation cephalosporin with immune enhancing function. Cefodizime can enhance the immune response. Animal models and human studies in vitro and in vivo have shown that the drug can activate macrophages and increase their phagocytic activity and bactericidal rate. In vivo, cefodizime prolongs the survival of infected animals, including those infected with drug-resistant bacteria or experimentally immunocompromised. [0003] Cefodizime, its chemical name is: (6R, 7R)-7-[(2-amino-4-thiazolyl)-(methoxyimino)acetamido]-3-[[(5-carboxymethyl -4-methyl-2-thiazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, molecular formula: C 20 h 20 N 6 o 7 S 4 Molecular weight: 584, structura...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/14A61P31/04C07D501/36C07D501/12
Inventor 罗诚
Owner 罗诚