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Simiaoyongan decoction active site dry extract powder and preparation method of clinical medicinal preparation by using dry extract powder

A technology of active parts and pharmaceutical dosage forms, applied in the field of Simiao Yong'an Decoction active part group dry cream powder, can solve the problems of inconvenient carrying and storage, low content of effective anti-inflammatory substances, poor compliance, etc., and achieve fast adsorption speed , Low production equipment requirements, high physical and chemical stability

Inactive Publication Date: 2013-02-13
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the technical problems of low content of effective anti-inflammatory substances in Simiao Yong'an Decoction, poor compliance and inconvenient taking, carrying and storage, and provides a dry cream powder of active parts of Simiao Yong'an Decoction and The preparation method of preparing clinical drug dosage form by using its dry cream powder

Method used

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  • Simiaoyongan decoction active site dry extract powder and preparation method of clinical medicinal preparation by using dry extract powder

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Effect test

specific Embodiment approach 1

[0016] Embodiment 1: The preparation method of Simiao Yong'an Decoction active part mass dry cream powder according to the present embodiment is carried out according to the following steps:

[0017] 1. Weigh 2.5 to 3.5 parts of honeysuckle, 2.5 to 3.5 parts of Scrophulariaceae, 1.5 to 2.5 parts of Angelica and 0.5 to 1.5 parts of licorice, and then add 8 to 16 parts of the total mass of honeysuckle, scrophulariaceae, angelica and licorice. times the amount of water, decocting 2~4 times, each time decocting 0.5~2h, collecting the filtrate after filtration, and concentrating the obtained filtrate under reduced pressure to a relative density of 1.05~ 1.25 to obtain concentrated liquid medicine;

[0018] 2. Add ethanol with a volume concentration of 85% to 95% to the concentrated medicinal liquid obtained in step 1, and make the concentrated liquid alcohol-sink until the volume concentration of ethanol in the concentrated medicinal liquid is 60% to 80%, stand still for 12 to 36 h...

specific Embodiment approach 2

[0023]Specific embodiment two: the difference between this embodiment and specific embodiment one is: the mass parts of honeysuckle, Scrophulariaceae, angelica and licorice in step one are 3, 3, 2 and 1, and other steps and parameters are the same as in specific embodiment one same.

specific Embodiment approach 3

[0024] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the temperature of the concentrated filtrate in Step 1 is 80° C., and other steps and parameters are the same as Embodiment 1 or 2.

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Abstract

The invention relates to a simiaoyongan decoction active site dry extract powder and a preparation method of a clinical medicinal preparation by using the dry extract powder, and aims at solving the technical problems that effective anti-inflammatory substances in the simiaoyongan decoction are low in content and poor in compliance and the simiaoyongan decoction is inconvenient to take, carry and store. The preparation method comprises the following steps of: extracting honeysuckle, figwort root, Chinese angelica and liquorice with water, precipitating with ethanol, reclaiming ethanol from supernate, and concentrating; adding sodium hydroxide liquid, collecting supernate, adding hydrochloric acid liquid, and collecting supernatant liquid; passing the supernatant liquid through a resin column, removing washing water, collecting ethanol eluent, concentrating, and drying to obtain the simiaoyongan decoction active site dry extract powder; and adding auxiliary materials to prepare various clinical preparations. The method does not use other organic solvents except ethanol, is simple in process flow, low requirement on production equipment and low in cost, realizes the content of general flavone of over 60 percent, and is applicable to industrial production.

Description

technical field [0001] The invention relates to a dry ointment powder of active parts of Simiao Yong'an Decoction and a preparation method for preparing clinical drug dosage forms by using the dry ointment powder. Background technique [0002] Simiao Yong'an Decoction was recorded in Bao Xiangao's "Experiencing Prescriptions New Edition" in the Qing Dynasty. The formula is composed of honeysuckle, scrophulariae, angelica and licorice. Among them, honeysuckle can clear both qi and blood, clear away heat and detoxify, and is the king's medicine; angelica is the qi in the blood. Medicine, nourishes blood and activates blood, promotes qi and relieves pain, and has the meaning of removing blood stasis and promoting new life. It is a ministerial drug; Scrophulariaceae purifies fire and detoxifies, clears heat and nourishes yin, can help honeysuckle to clear away heat and detoxify, and is an adjuvant drug; licorice and honeysuckle strengthen the effect of clearing away heat and deto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61P29/00A61P39/06A61P7/02A61P9/00
Inventor 李云涛贾博宇任瑞涛吴志军王丽娜单钰毓李殿明王英新
Owner 哈药集团中药二厂
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