Method for producing enramycin by fermenting

Abstract

The invention relates to a method for producing enramycin by fermenting. According to the method, bactericidin streptomycete FYFJ03 is taken as a fermenting strain; during a fermenting process for constant temperature culturing, different sugar concentrations are fed under different stages; the dissolved oxygen of fermentation liquor is improved; and the fermentation level of the enramycin is increased. The method is simple and easy to carry out. After the fermentation is performed according to the method during the fermenting culturing process, the fermentation level of the enramycin is increased by about 20%.

Description

technical field

[0001] The invention relates to the technical field of fermentation, in particular to a method for fermenting and producing enramycin. Background technique

[0002] Enramycin (Enramycin), also known as Enlaimycin, Ensu, Anlaimycin, Persistomycin, belongs to a kind of polypeptide antibiotics. Polypeptide antibiotics, amino acid molecules form a cyclic polypeptide, and fatty acid molecules are connected to the aspartic acid at the end. According to the fatty acid molecules at the end of the molecule, it can be divided into enramycin A and enramycin B. Generally speaking, enlamycin Mycin is a mixture of these two components, and enramycin is a polypeptide antibiotic produced by fermentation of actinomyces (Streptomyces fungiedious) isolated from soil. He has a strong inhibitory effect on Gram-positive bacteria, and the mechanism of action is to hinder the synthesis of the cell wall of Gram-positive bacteria. The sensitive bacteria mainly include various Gram-p...