Method for detecting quality of safflower Xiaoyao tablet
A quality inspection method, free technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of ineffective control of product quality, simple quality control detection methods, and inability to accurately and comprehensively reflect the intrinsic quality of products, etc. To achieve basically the same medicine and curative effect, perfect quality control, stable and reliable quality
Active Publication Date: 2013-02-27
JIANGXI POZIN PHARMA
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However, the current research on Honghua Xiaoyao Tablets only focuses on the TLC identification method of Angelica, Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Bupleurum and Mint in the prescription and the content determination of Radix Paeoniae Alba by HPLC.
Obviously, for Honghua Xiaoyao Tablets, a compound preparation composed of 9 traditional Chinese medicines, its quality control testing method is too simple, and cannot be more accurate and comprehensive to reflect the internal quality of the product, nor can it be used in the production process and effectively monitor product quality. control
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Embodiment 1
[0040] Example 1: The standard fingerprint of Honghua Xiaoyao Tablets was established.
[0041] (1) Instruments and reagents: High-performance liquid chromatography: Shimadzu LC-10ATvp high-performance liquid chromatography (SPD-M10Avp detector, CLASS-VP software); CNC ultrasonic cleaner: KQ-250DB, Kunshan Ultrasonic Instrument Ltd.; one hundred thousandth balance: Shimadzu AUW220; one ten thousandth balance: AB104-N type, Mettler-Toledo; Millipore ultrapure water meter.
[0042] Acetonitrile: Chemical Branch of Shandong Yuwang Experimental Co., Ltd.; Methanol: Shanghai Zhenxing Chemical Factory No. 1; Phosphoric acid (excellent grade): Tianjin Fine Chemicals Development Co., Ltd.; ultrapure water.
[0043] Paeoniflorin reference substance: National Institute for the Control of Pharmaceutical and Biological Products; Honghua Xiaoyao Tablet: Jiangxi Puzheng Pharmaceutical Co., Ltd.
[0044] (2) Preparation of reference solution.
[0045] Take about 23mg of paeoniflorin, wei...
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Abstract
The invention discloses a method for detecting quality of a safflower Xiaoyao tablet and belongs to the technical field of drug quality control. The method comprises the following steps of contrast solution preparation, tested sample preparation, chromatographic condition arrangement, standard finger-print drawing based on a paeoniflorin peak as a reference peak, and finger-print quality control. The method builds a standard finger-print by the high performance liquid chromatography, acquires quantization parameters by the finger-print, can effectively control preparation quality, and has high precision, good stability and good repeatability.
Description
technical field [0001] The invention belongs to the technical field of drug quality control, in particular to a fingerprint detection method of Honghua Xiaoyao Tablets. Background technique [0002] Honghua Xiaoyao Tablets are composed of nine herbs including angelica, white peony root, Atractylodes macrocephala, Poria cocos, safflower, saponins, bamboo leaf Bupleurum, peppermint, and licorice. Chest pain, dizziness, loss of appetite, irregular menstruation, breast pain or chloasma on the face. [0003] As traditional Chinese medicine has the characteristics of complex and changeable ingredients, many active ingredients, and unclear medicinal and toxic ingredients, Honghua Xiaoyao Tablet, as a Chinese patent medicine, does not come from any single active ingredient. It is the result of a variety of active ingredients working together. However, the current research on Honghua Xiaoyao Tablets only focuses on the TLC identification method of Angelica, Radix Paeoniae Alba, Rad...
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IPC IPC(8): G01N30/88
Inventor 肖军平饶毅吴永忠余宝平邹贵阳
Owner JIANGXI POZIN PHARMA