Pharmaceutical compositions of co-crystals of tramadol and coxibs

A technology of composition and co-crystal, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, antipyretic drugs, etc., to achieve the effects of enhancing drug release rate, increasing bioavailability, and enhancing stability

Active Publication Date: 2013-02-27
ESTEVE PHARMA SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] However, no specific pharmaceutical formulation has been described in the art that would allow these new co-crystals to exhibit these advantages or even improve them when used in practical medical applications, for example when used in human medicine

Method used

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  • Pharmaceutical compositions of co-crystals of tramadol and coxibs
  • Pharmaceutical compositions of co-crystals of tramadol and coxibs
  • Pharmaceutical compositions of co-crystals of tramadol and coxibs

Examples

Experimental program
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Embodiment Construction

[0041] In a preferred embodiment, the fluid (such as containing 2% SLS (sodium lauryl sulfate; S odium L auryl S ulphate) in 0.1N HCl solution or pH 12 buffer solution containing 1% SLS) (racemic)-tramadol HCl-celecoxib (1:1 ) percentage of co-crystals will be greater than 85% within the first 30 minutes and / or will be greater than 90% within the first 45 minutes (eg in the USP paddle test).

[0042] In a preferred embodiment, "solubility enhancing polymer" is selected from caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer or other hydrophilic polymers such as copovidone (copolymer of 1-vinyl-2-pyrrolidone and vinyl acetate; VA64), povidone, poloxamer (nonionic polyoxyethylene-polyoxypropylene copolymer, e.g. ), cyclodextrin Polyethylene glycol and its derivatives (PEG) and glyceryl behenate Or selected from polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer or other hydrophilic polymers such as copovidone (copolymer of ...

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Abstract

The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib, processes for preparation of the same and their use as medicaments, more particularly for the treatment of pain.

Description

technical field [0001] The present invention relates to an oral pharmaceutical composition comprising a co-crystal of tramadol (tramadol) and celecoxib (celecoxib, celecoxib), its preparation method and its use as a medicine, more specifically, with Use in the treatment of pain. Background technique [0002] Pain is a complex response that has been functionally categorized into sensory, voluntary, motor and affective components. The sensory aspect includes information about the location and intensity of stimuli, while the adaptive component can be viewed as the activation of endogenous pain modulation and motor planning for the escape response. The affective component appears to include assessments of pain discomfort and stimulus threat as well as negative emotions triggered by memories and situations of painful stimuli. [0003] In general, pain conditions can be divided into chronic and acute. Chronic pain includes neuropathic pain (neuropathic pain) and chronic inflamm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20C07C59/64A61K31/135A61K31/415
CPCA61K9/2018A61K47/34A61K9/2027A61K31/135A61K47/32A61K31/415A61P19/00A61P19/02A61P21/00A61P25/02A61P25/04A61P29/00A61P43/00A61P3/10A61K2300/00A61K9/20C07C59/64A61K31/045A61K31/4162A61K31/05A61K31/18A61K31/63
Inventor 路易斯·佐勒兰扎尼阿尔贝特·法利韦内阿尔迪亚
Owner ESTEVE PHARMA SA
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