5 results about "Tramadol hcl" patented technology

The application belongs to the technical field of organic compounds, and particularly relates to a preparation method of 3-[3-(dimethylamino)methyl-1-cyclohexen-2-yl]phenol hydrochloride and isomers thereof. The preparation method comprises the following steps: heating and reacting compound III with an acid, then adding sodium hydroxide to adjust the pH value to be alkaline; then continuously adding an extractant to extract, separating to obtain a water layer, introducing carbon dioxide into the water layer, and precipitating white solids in the water layer; filtering to obtain a mixture of compound VI and compound VII; dissolving the mixture of compound VI and compound VII in a polar organic solvent, introducing hydrogen chloride gas, and performing crystallization and filtration to obtain compound I; and concentrating, filtering and recrystallizing the mother liquor to obtain compound II. The application simplifies the preparation process of tramadol analogs and integrates the process into two-step reactions; the molecular structure of tramadol hydrochloride is designed to optimize the existing problems of individual differences in analgesic effect and side effects of original tramadol and analogs.

1. Name of the designed product: packaging box (Tramadol hydrochloride injection). 2. Use of the designed product: the designed product is used for packaging medicines. 3. Design points of the designed product: the pattern of the product. 4. Picture or photo best indicating the design points: front view.

The invention belongs to the technical field of organic compounds, and particularly relates to a preparation method of 3-[3-(dimethylamino) methyl-1-cyclohexene-2-yl] phenol hydrochloride and an isomer thereof. The preparation method comprises the following steps: carrying out heating reaction on a compound III and acid, then adding sodium hydroxide, and adjusting the pH value to be alkaline; continuously adding an extracting agent for extraction, separating to obtain a water layer, introducing carbon dioxide into the water layer, separating out a white solid from the water layer, and filtering to obtain a mixture of a compound VI and a compound VII; dissolving the mixture of the compound VI and the compound VII in a polar organic solvent, introducing hydrogen chloride gas, crystallizing and filtering to obtain a compound I; and carrying out concentration, filtration and recrystallization on the mother liquor to obtain a compound II. The preparation process of the tramadol analogue is simplified and is integrated into two-step reaction; the molecular structure of tramadol hydrochloride is designed, and the problem that the individual differences of the analgesic effect and side effect of the original tramadol and analogues are large is solved.

The present invention relates to the combination of ibuprofen in the form of a pharmaceutically acceptable salt and tramadol or a pharmaceutically acceptable salt thereof, for use in the treatment of pain in humans, wherein the dosage of ibuprofen in the combination is between 350 mg and 450 mg and the dosage of tramadol is between 35 mg and 40 mg, expressed as an equivalent weight of tramadol hydrochloride. The combination is suitable for the treatment of moderate to severe pain, of chronic or acute origin and is particularly effective for those patients suffering from more severe pain. It also relates to a pharmaceutical composition comprising said fixed dose combination of ibuprofen and tramadol.