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Compound consisting of parecoxib sodium and tramadol hydrochloride, and application of compound

A technology of tramadol hydrochloride and parecoxib sodium, which is applied in the field of complexes composed of parecoxib sodium and tramadol hydrochloride, which can solve the problems of long pain treatment period and unsatisfactory pain effect, and improve the permeability , Increase the drug loading and encapsulation efficiency, improve the effect of stability and encapsulation efficiency

Inactive Publication Date: 2018-02-02
赛隆药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the course of treatment for pain with a single drug is long, so mixed drugs are often used to treat pain. For example, the prior art discloses the combination of tramadol and parecoxib sodium to treat pain after radical resection of esophageal cancer, and tramadol combined with parecoxib sodium Buna is used to treat postoperative pain in gynecological laparoscopic surgery, etc.
However, judging from the combined treatment effects disclosed in the prior art, the combination of tramadol and parecoxib sodium is not ideal for the treatment of pain, and there are also great problems in the selection of dosage forms after the combination of the two

Method used

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  • Compound consisting of parecoxib sodium and tramadol hydrochloride, and application of compound
  • Compound consisting of parecoxib sodium and tramadol hydrochloride, and application of compound
  • Compound consisting of parecoxib sodium and tramadol hydrochloride, and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 A compound composed of parecoxib sodium and tramadol hydrochloride

[0042] The complex is a co-crystal hydrate, and the molecular number ratio of parecoxib sodium, tramadol hydrochloride and water in the co-crystal hydrate is 1:2:1, and the X- Ray diffraction has characteristic peaks at 8.2°, 10.5°, 17.3°, 20.4°, 22.7° and 25.8°.

Embodiment 2

[0043] Example 2 A compound composed of parecoxib sodium and tramadol hydrochloride

[0044] The complex is a co-crystal hydrate, and the molecular number ratio of parecoxib sodium, tramadol hydrochloride and water in the co-crystal hydrate is 1:2:1, and the X- Ray diffraction has characteristic peaks at 4.3°, 8.2°, 10.5°, 13.7°, 17.3°, 19.4°, 20.4°, 22.7°, 25.8°, 28.6°, 30.4° and 36.5°, such as figure 1 As shown, the relative intensities of the above characteristic peaks are as follows:

[0045]

[0046]

Embodiment 3

[0047] Example 3 A compound composed of parecoxib sodium and tramadol hydrochloride

[0048] The complex consists of 1.5 g of aspirin and 1 g of co-crystal hydrate.

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PUM

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Abstract

The invention provides a compound consisting of parecoxib sodium and tramadol hydrochloride, and application of the compound. The compound is a eutectic hydrate; the molecule number ratio of the parecoxib sodium to the tramadol hydrochloride to the water in the eutectic hydrate is 1:2:1; X-ray diffraction represented by 2theta has characteristic peaks at the positions of 8.2 degrees, 10.5 degrees,17.3 degrees, 20.4 degrees, 22.7 degrees and 25.8 degrees; the parecoxib sodium and the tramadol hydrochloride are combined, the combination mode is bound by hydrogen bonds, the eutectic hydrate formed by connecting the hydrogen bonds is more stable, and the pharmacokinetic property is obviously improved; and although the action mechanisms of the parecoxib sodium and the tramadol hydrochloride are different, the compound formed by the parecoxib sodium and the tramadol hydrochloride has an unexpected synergistic effect and has a positive application prospect in the field of treatment on pain caused by ankylosing spondylitis.

Description

technical field [0001] The invention belongs to the field of drugs for treating pain and anti-inflammation, in particular to a compound composed of parecoxib sodium and tramadol hydrochloride and its application. Background technique [0002] Pain is a complex response that has been functionally categorized into sensory, spontaneous, motor, and affective components. In general, pain can be divided into chronic and acute. Chronic pain includes neuropathic pain and chronic inflammatory pain, such as arthritis, or pain of unknown origin, such as fibromyalgia. Acute pain often follows non-neural tissue damage, such as tissue damage from surgery or inflammation, or migraine. [0003] Currently, there are many drugs used to treat or manage pain, such as opioids, morphine derivatives, etc. Morphine derivatives are indicated for the palliative treatment of acute pain in humans, obtaining an analgesic effect through their action on morphine receptors, preferably μ-receptors. Amon...

Claims

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Application Information

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IPC IPC(8): A61K31/42A61K9/19A61K47/55A61K47/36A61K47/40A61P29/00A61P19/08A61P19/02A61K31/137
CPCA61K31/42A61K9/19A61K31/137A61K47/36A61K47/40A61K2300/00
Inventor 李剑峰周文
Owner 赛隆药业集团股份有限公司
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