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Chewing tablet of tramado hydrochloride and its preparation method

The technology of paracetamol and trama and chewable tablets is applied in the field of medicine, which can solve the problem that the preparation cannot be generally accepted by patients, and achieve the effects of good taste, long action time and high analgesic intensity of the preparation.

Active Publication Date: 2006-02-15
NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

There is no chewable tablet preparation of the pharmaceutical composition at present, and its preparation cannot be generally accepted by the majority of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The preparation method of paracetamol tramadol chewable tablet of the present invention is as follows: Weigh acetaminophen, tramadol hydrochloride (through 100 mesh sieve), filler, corrective agent and partial disintegrating agent, add after mixing uniformly Appropriate amount of wetting agent or binder is granulated, dried (50°C), the lubricant is mixed evenly with the dry granules, and compressed into tablets.

[0025] components

[0026] Preparation Process:

[0027] Weigh tramadol hydrochloride, acetaminophen, mannitol, microcrystalline cellulose, aspartame, sodium carboxymethyl starch, and peppermint essence according to the above prescription, put them into a rapid stirring granulator and mix well, add Appropriate amount of 7% starch slurry, made of soft materials, granulated with 16 mesh sieve, ventilated and dried at 50°C±5°C until the weight loss of the granules is about 2.5%, the dry granules are granulated through a 20 mesh sieve, and mixed with mag...

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PUM

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Abstract

The invention provides a novel preparation using tramadol hydrochloride and paracetamol compositions as the main medicaments, i.e. aminophen tramadol chewing tablet. The weight ratio of tramadol hydrochloride and paracetamol is 0.1:1-0.2:1, and the adjuvant employs medicinal excipient, which includes 50.1-83.7% of water-soluble bulking agent, crumbling agent, lubricating agent, flavoring agent, moistening agent or binding agent.

Description

technical field [0001] The invention relates to a new preparation method with tramadol hydrochloride and acetaminophen as the main agent, i.e. acetaminophen chewable tablet, which belongs to the field of medicine. Background technique [0002] Acetaminophen is an antipyretic and analgesic drug that can treat symptoms such as headache, fever, pain in limbs, and general malaise; tramadol hydrochloride is a commonly used analgesic and a weak opioid receptor antagonist, both of which are covered by national medical insurance drug. The two are used in combination to form a pharmaceutical composition, which has the characteristics of quick onset, long action time, high analgesic strength, and no addiction compared with a single common tablet. There is no chewable tablet preparation of the pharmaceutical composition at present, and its preparation cannot be generally accepted by the majority of patients. Contents of the invention [0003] The invention relates to a new type of ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/20A61P25/04A61P29/00
Inventor 刘实贾树田张现涛李伟斌钱淑芸
Owner NANJING HAILING TRADITIONAL CHINESE MEDICINE RES CO LTD
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