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Glipizide sustained-release dropping pill for treating diabetes and preparation method thereof

A technology for glipizide and sustained-release dropping pills, applied in the pharmaceutical field, can solve the problems of cumbersome tablet production process, unfavorable ability of patients to seek medical treatment, physical harm to staff, etc., achieve controllable drug release time and improve bioavailability , the effect of reducing the number of doses

Inactive Publication Date: 2013-03-13
北京博智绿洲医药科技有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0003] The existing commercially available glipizide tablet and glipizide controlled-release tablet of this medicine, as everyone knows, the production process of tablet is loaded down with trivial details, and the cost is high, thereby makes the patient's drug cost also increase thereupon, is unfavorable for raising the general public. Patients' ability to seek medical treatment is also not conducive to improving the overall health of society
Especially in the preparation process, due to the granulation process, a large amount of dust pollution will be generated, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Now with several groups of specific examples, the preparation method of glipizide sustained-release dripping pills of the present invention is further described:

[0023] First group:

[0024] Based on the total weight of 100g, weigh 30% of the matrix PEG4000, 25% of PEG6000, 23% of stearic acid, 7% of glyceryl monostearate, and 15% of the raw material glipizide; place the matrix in a heating container to heat and stir Make it melt, add the corresponding proportion of glipizide, stir fully, and under the condition of heat preservation, drip the molten or mixed liquid medicine into the condensation column filled with simethicone oil, wherein the temperature when heating and melting is 55°C, the temperature of the upper part of the condensate is 35°C, and the temperature of the bottom is 7°C; take it out after forming.

[0025] The obtained product has a 2-hour cumulative release percentage of 35-55%, a 6-hour cumulative release percentage of 59-78%, and a 10-hour cumula...

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PUM

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Abstract

The invention belongs to the technical field of pharmacy, and in particular relates to a glipizide sustained-release dropping pill for treating diabetes and a preparation method thereof. Based on glipizide sustained-release dropping pill, the drug provided by the invention is prepared by existing preparation technology of dropping pill. Compared to the prior art, the invention is the supplement for the defects of existing drug form production, and provides a drug, which has advantages of high bioavailability, rapid effectiveness, long-acting effect, little toxic or side effect, high drug content, small and accurate dosage, convenient usage, low price and convenience for carrying.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a drug glipizide slow-release preparation for treating anti-diabetes and a preparation method thereof. Background technique [0002] Glipizide is a second-generation sulfonylurea hypoglycemic drug. It can not only promote the secretion of insulin by pancreatic β cells, but also enhance the effect of insulin on target tissues. It is effective for most patients with type 2 diabetes, and can reduce fasting and postprandial blood sugar, and reduce glycosylated hemoglobin (HbAlc) by 1% to 2%. The prerequisite for such drugs to stimulate insulin secretion from islet b cells is that the islet b cells also have certain functions of synthesizing and secreting insulin. It is suitable for patients with mild and moderate type 2 diabetes who are not satisfied with the curative effect of diet control and physical exercise for 2 to 3 months. The islet b cells of such patients wit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/64A61K47/34A61K47/32A61P3/10
Inventor 曲韵智王金强振君
Owner 北京博智绿洲医药科技有限公司
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