Drop pills for treating oral disease
A technology of dripping pills and preparations, which is applied in the directions of pill delivery, medical preparations containing active ingredients, and digestive system, can solve the problems of inconvenient application for the elderly and children, increasing the incidence of adverse reactions, and inability to achieve quantitative drug delivery, etc. Achieve the effect of improving bioavailability, avoiding first-pass effect, and avoiding gastrointestinal irritation symptoms
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[0028] Now with the test of several groups of specific examples and the results thereof, the preparation method of Jinhoujian dripping pills of the present invention will be further described.
[0029] Group 1: Tests with a single matrix
[0030] [formula]
[0031] (Preparation is carried out according to the process given in [Preparation Method of Dripping Pill Raw Materials], and the dry powder containing the active ingredient of the medicine can be obtained.)
[0032] 1. Raw materials - dry powder containing active pharmaceutical ingredients prepared by the previous method;
[0033] 2. Substrate: polyethylene glycol 2000、4000、6000、8000、10000、20000 , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;
[0034] 3. Proportioning (in g, in parts by weight): drug extract: matrix = 1:1 to 1:9.
[0035] [test results]
[0036] Test 1: In ...
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