Preparation method and quality control method of sugar-free compound fructus momordicae antitussive particles

Abstract

The invention discloses a preparation method and quality control method of sugar-free compound fructus momordicae antitussive particles. Based on the original preparation process of compound fructus momordicae antitussive particles, the inventor removes a large amount of sugar powder in the original process, and uses a proper amount of non-sugar adjuvant instead; the particles are prepared after materials are stirred to be soft, thus not only reducing the viscosity of the medicine, but also being beneficial to particle preparation; and the prepared particles are good in granularity, uniform in color and good in dissolvability. In addition, to alleviate the bitter taste, a proper amount of glycoprotein, steviosin, xylitol or sodium cyclamate which contains no heat and has no side effect is selected to be added as the corrigent, so the compound fructus momordicae antitussive particles are comfortable in mouthfeel, convenient to take, and also applicable to patients suffering from diabetes, hypertension, hyperlipemia and obesity; and worry about side effects is unnecessary when the particles are taken. To ensure the medicine use safety and effectiveness of the compound fructus momordicae antitussive particles product, the inventor adds qualitative identification of ursolic acid and quantitative measurement of fructus momordicae saponin V, to ensure the medicine use safety and effectiveness, and improve the quality level of the relevant product of the compound fructus momordicae antitussive particles.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a preparation method and a quality control method of sugar-free compound Luo Han Guo Zhike granules. Background technique [0002] Traditional Chinese medicine preparations are easy to take and effective, and are deeply loved by patients. However, with the increase of people's diseases caused by excessive consumption of sugar, especially patients with diabetes, hypertension, hyperglycemia and obesity, when taking traditional Chinese medicine preparations, they are more eager to satisfy the premise of high sweetness and low calorie. , a sugar-free non-nutritive sweet traditional Chinese medicine preparation that is safe, healthy and does not participate in human metabolism. [0003] Compound Mangosteen Zhike Granules is a variety recorded in the standard traditional Chinese medicine preparations issued by the Ministry. It is a granule made by e...

AI Technical Summary

Problems solved by technology

However, since the granules use sucrose as an auxiliary material and have high sugar content, they are not suitable for patients with diabetes, hypertension, hyperlipidemia and obesity.

[0004] At present, the drug standard implemented by Compound Luo Han Guo Zhi Ke Granules is WS3-B-0583-91. This standard does not control the content of mogroside V, the active ingredient in the drug, and there are hidden dangers of uncertain drug safety and effectiveness. quality