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Gd2O3-TiO2 composite nanoparticle as well as preparation method and application thereof

A nanoparticle, 20wt%-80wt% technology, applied in the field of Gd2O3 composite TiO2 nanoparticles and its preparation, can solve the problems of short retention time, unfavorable test, etc., and achieve the effect of improving contrast performance

Active Publication Date: 2013-04-03
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, individual Gd 2 o 3 Due to the small size of nanoparticles, they are easily excreted quickly after being metabolized by the kidneys, and the retention time in the body is short, which is not conducive to the test in MRI.
Moreover, superparamagnetic Gd 2 o 3 Nanoparticle contrast agents generally only have the function of medical imaging diagnosis, and it is difficult to combine with biomolecules or drug molecules to perform therapeutic functions at the same time

Method used

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  • Gd2O3-TiO2 composite nanoparticle as well as preparation method and application thereof
  • Gd2O3-TiO2 composite nanoparticle as well as preparation method and application thereof
  • Gd2O3-TiO2 composite nanoparticle as well as preparation method and application thereof

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preparation example Construction

[0070] The preparation method of nanoparticle suspension or sol of the present invention comprises the following steps:

[0071] (i) trivalent gadolinium salt is dissolved in the polyol solution, and the polyol solution of alkali is added to react;

[0072] (ii) adding the tetravalent titanium salt solution dropwise to the reaction solution prepared in step (i), reacting to obtain the nanoparticle suspension or sol according to claim 4, wherein,

[0073] The trivalent gadolinium salt is selected from: gadolinium nitrate, gadolinium chloride, gadolinium nitrate hexahydrate, gadolinium chloride hexahydrate or combinations thereof;

[0074] The alkali is selected from: sodium hydroxide, potassium hydroxide or a combination thereof;

[0075] Each polyhydric alcohol is independently selected from: diethylene glycol or diethylene glycol or a combination thereof;

[0076] The tetravalent titanium salt is selected from: tetrabutyl titanate or titanium tetrachloride or a combination ...

Embodiment 1

[0128] Weigh gadolinium nitrate hexahydrate (Gd(NO 3 ) 3 ·6H 2 O) 6mmol, dissolve it in 20mL diethylene glycol, and stir magnetically at 140°C to ensure that Gd(NO 3 ) 3 ·6H 2 O is fully dissolved to obtain A solution for use.

[0129] Weigh 10 mmol of sodium hydroxide (NaOH), dissolve it in 40 mL of diethylene glycol, and stir it magnetically to ensure that NaOH is fully dissolved, and obtain B solution for use.

[0130] Add solution A into solution B, stir magnetically at 140°C for 1 hour, and stir magnetically at 180°C for 4 hours. The reaction solution was dialyzed: the molecular weight cut-off of the dialysis bag was 3500, the water was changed once in 12 hours, and the dialysis was performed 3 times, and the water was changed once in 24 hours, and the dialysis was performed 3 times.

[0131] Add 10 mL of tetrabutyl titanate solution with a molar concentration of 1.8 mol / L to the above dialysate dropwise, and continue stirring;

[0132] After reacting for 8 hours, ...

Embodiment 2

[0138] Weigh gadolinium nitrate hexahydrate (Gd(NO 3 ) 3 ·6H 2 O) 6mmol, dissolve it in 20mL diethylene glycol, and stir magnetically at 140°C to ensure that Gd(NO 3 ) 3 ·6H 2 O is fully dissolved to obtain A solution for use.

[0139] Weigh 10 mmol of sodium hydroxide (NaOH), dissolve it in 40 mL of diethylene glycol, and stir it magnetically to ensure that NaOH is fully dissolved, and obtain B solution for use.

[0140] Add solution A into solution B, stir magnetically at 140°C for 1 hour, and stir magnetically at 180°C for 4 hours. The reaction solution was dialyzed: the molecular weight cut-off of the dialysis bag was 3500, the water was changed once in 12 hours, and the dialysis was performed 3 times, and the water was changed once in 24 hours, and the dialysis was performed 3 times.

[0141] 10 mL of tetrabutyl titanate solution with a molar concentration of 0.6 mol / L was added dropwise to the dialysate, and the stirring was continued.

[0142] After reacting for ...

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Abstract

The invention discloses a Gd2O3-TiO2 composite nanparticle as well as a preparation method and application thereof. Trivalent gadolinium salt is dissolved in polyhydric alcohol solution, alkaline polyhydric alcohol solution is added to have reaction, then tetravalent titanium salt solution is dropwise added to have reaction to obtain nanoparticle suspension or sol, and separation and free-drying are carried out to obtain the Gd2O3 and TiO2 composite nanoparticle. The Gd2O3-TiO2 composite nanparticle disclosed by the invention has a radiography function and also has a medical treatment function.

Description

technical field [0001] The present invention relates to nanoparticles, in particular to Gd 2 o 3 Composite TiO 2 Nanoparticles and methods for their preparation and applications. Background technique [0002] Magnetic resonance imaging (MRI) technology has now become an important medical diagnostic method, which can effectively detect tissue necrosis, local ischemia and various malignant lesions such as tumors, and can carry out early diagnosis, and may also be helpful for organ transplantation. Wait for monitoring. It has the advantages of high sensitivity, clear image, and non-invasive inspection. [0003] With the widespread application of magnetic resonance imaging in clinic, people place higher hopes on MRI, especially to improve its resolution of tissue, so that some smaller lesions can be found as early as possible. MRI contrast agents can change the relaxation rate of water protons in local tissues and improve the imaging contrast between normal and diseased par...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/06A61K41/00A61K9/14A61K9/10A61P35/00
Inventor 吴爱国马雪华沈折玉
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI