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Amphipathic nano-micelle with POSS based capping end sensitive to metal ions and preparation method of amphipathic nano-micelle

A kind of metal ion, nano micelle technology, applied in the field of amphiphilic nano micelle and its preparation

Inactive Publication Date: 2013-04-03
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there have been no reports about POSS-terminated amphiphilic nanomicelles, especially POSS-terminated amphiphilic nanomicelles with metal ion sensitivity.

Method used

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  • Amphipathic nano-micelle with POSS based capping end sensitive to metal ions and preparation method of amphipathic nano-micelle
  • Amphipathic nano-micelle with POSS based capping end sensitive to metal ions and preparation method of amphipathic nano-micelle
  • Amphipathic nano-micelle with POSS based capping end sensitive to metal ions and preparation method of amphipathic nano-micelle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Dissolve 5g POSS, 0.56g maleic anhydride and 0.028g p-diphenol in 40mL benzene, pass nitrogen gas to remove oxygen, react at 80~110℃ for 12~24 hours, after distilling off benzene, use a volume ratio of 1:1 petroleum ether / diethyl ether mixed solution for extraction and centrifuge to separate the precipitate to obtain POSS-MA;

[0042] (2) Dissolve 1g POSS-MA, 1.64g polyethylene glycol (molecular weight 2000, ie PEG2000), 0.0205g p-diphenol, 0.011g toluenesulfonic acid in 40mL benzene, blow nitrogen to remove oxygen, at 125~140℃ After reacting for 24~36 hours, after benzene was removed by distillation, extraction was carried out with a mixed solution of petroleum ether / diethyl ether with a volume ratio of 1:1, and the precipitate was separated by a centrifuge to obtain POSS-MA-PEG2000;

[0043] (3) 2g POSS-MA-PEG2000 (6.77×10 -4 mol), 2,6-pyridinedicarboxylic acid (DPA, 6.77×10 -4mol), 0.0064g p-toluenesulfonic acid, 0.0106g p-diphenol were dissolved in 40mL cycloh...

Embodiment 2~ Embodiment 10

[0048] Steps (1) to (5) are the same as in Example 1, but the metal ion / amphiphile molar ratio (M / L) in step (6) is changed, and a series of mixed solutions with different M / L are prepared. These mixed solutions are respectively Using ultraviolet spectrophotometer (UV) to measure transmittance, dynamic photomorphism (DLS) to measure particle size, and transmission electron microscope (TEM) to observe assembly morphology, the metal ion responsiveness was compared and studied simultaneously. The results are shown in the following table:

[0049] Example 2 3 4 5 6 7 8 9 10 M / L 0 0.1 0.3 0.6 0.8 1.0 1.2 1.5 2.0 UV (T%) 2.69 4.01 19.31 36.17 28.66 2.33 8.38 35.85 38.38 DLS (nm) 227.5 215.6 191.6 183.9 239.3 315.8 192.9 144.8 139.9

[0050] Carry out comparative analysis in conjunction with the result of embodiment 1, transmittance and particle size change as figure 1 with figure 2 shown. Such as image 3 with Fi...

Embodiment 11~13

[0052] Step (1) to step (5) are the same as in Example 1, change ZnCl in step (2) 2 for FeCl 3 , CuCl 2 、 TiCl 4 , respectively prepare a mixed solution with M / L of 0.5. The above-mentioned mixtures were measured by ultraviolet spectrophotometer (UV) to measure the transmittance, dynamic light state radiation (DLS) to measure the particle size, and transmission electron microscope (TEM) to observe the assembly morphology to compare and study their metal ion responsiveness simultaneously. The results are shown in the following table Shown:

[0053] Example 11 12 13 Metal Ion Type FeCl 3 CuCl 2 TiCl4 M / L 0.5 0.5 0.5 UV (T%) 33.17 26.32 38.59 DLS (nm) 194.1 245.8 138.6

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Abstract

The invention discloses an amphipathic nano-micelle with a POSS (Polyhedral Oligomeric Silsesquioxane) based capping end sensitive to metal ions and a preparation method of the amphipathic nano-micelle. POSS serves as a lyophobic end of an amphipathic macromolecule; the tail end of a hydrophilic chain is subjected to functional modification; 2,6-pyridinedicarboxylic acid is introduced as a coordination site; modified PEG (Polyethylene Glycol) has certain responsivity to the metal ions; the amphipathic molecule of the micelle is sensitive to the metal ions; the micelle is in a metastable state structure in a selective solvent; when the metal ion concentration in a surrounding environment is changed, the assemble form and volume of the micelle are changed quickly and significantly; and the micelle has potential application values in medicine loading, release controlling, molecule sensors and other aspects.

Description

technical field [0001] The invention belongs to the technical field of micelles, in particular to a POSS (Polyhedral Oligomeric Silsesquioxane, Polyhedral Oligomeric Silsesquioxane) group-terminated amphiphilic nano-micelle with metal ion sensitivity and a preparation method thereof. Background technique [0002] Micelles are a self-assembled structure with a solvent-repellent core and a solvation shell formed by microscopic phase separation of surfactants in selective solvents when they reach a certain concentration. The driving forces leading to the formation of solvophobic domains include hydrophobic interaction, electrostatic interaction, hydrogen bond interaction or metal coordination interaction. Nanomicelles with intelligent responsiveness will have broad application prospects in drug dissolution, stability and transport. [0003] Environmentally sensitive smart micelles are a type of nanomicelles that can rapidly change their structure, shape and performance under t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L71/08C08G65/48C08J3/07
Inventor 曾碧榕陈凌南戴李宗毛杰刘新瑜许一婷罗伟昂何凯斌
Owner XIAMEN UNIV
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