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Granules of solid traditional Chinese medicine particles and preparation method of granules

A technology of solid particles and granules, applied in the direction of block conveying, etc., can solve the problems of reduced volatile oil retention, pollution of the working environment, discomfort of operators, etc., to ensure the quality and effectiveness of drugs, shorten the process time, and improve the retention rate. Effect

Active Publication Date: 2015-04-15
ZHEJIANG JOLLY PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] 2. In the drying process of volatile oil clathrate, some volatile oil escapes and part of it is lost, the retention of volatile oil decreases, and it causes certain working environment pollution, and the operator feels uncomfortable;
[0012] 3. If further processing, granulation, granule drying and other processes are made into solid preparations such as tablets and capsules, the retention of volatile oil in these solid preparations will be further reduced to only about 50%, which will affect the effectiveness and quality of the drug

Method used

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  • Granules of solid traditional Chinese medicine particles and preparation method of granules

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Effect test

Embodiment 1

[0050] The weight ratio of the composition of this embodiment is: zedoary oil 2.5%, Wuling bacteria powder 36%, traditional Chinese medicine dry extract 32%, and other auxiliary materials 29.5%.

[0051] The preparation method of the granule containing zedoary oil, the method comprises the following steps:

[0052] 1) Extract zedoary into volatile oil, and extract other traditional Chinese medicines to make dry extract;

[0053] 2) Inclusion of volatile oil: take β-cyclodextrin to prepare a saturated aqueous solution, dissolve zedoary oil in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of zedoary oil: β-cyclodextrin = 1:6, Stir at room temperature for 3 hours at a stirring speed of 100 rpm, let stand overnight, remove the supernatant, vacuum filter the lower precipitate, and set aside;

[0054] 3) Put the wet zedoary oil inclusion compound and Wuling bacteria powder on the rotary granulator for pre-mixing and gran...

Embodiment 2

[0059] The weight ratio of the composition of this embodiment is: Chuanqiong oil: 3%, fermented Cordyceps powder 35%, Chinese medicine dry extract 25%, and other auxiliary materials 37%.

[0060] The preparation method of the granule containing Chuanqiong oil, the method comprises the following steps:

[0061] 1) Chuanqiong is extracted into volatile oil, and other traditional Chinese medicines are extracted into dry extract;

[0062] 2) Inclusion of volatile oil: Take β-cyclodextrin to prepare a saturated aqueous solution, dissolve Chuanqiong oil in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of Zedoary oil: β-cyclodextrin=1:5 , stirred at 25°C for 5 hours, allowed to stand overnight, removed the supernatant, filtered the lower part of the precipitate under reduced pressure, and set aside;

[0063] 3) Put the wet zedoary oil clathrate and fermented Cordyceps powder on the swing granulator to pre-mix and granulat...

Embodiment 3

[0067] The weight ratio of the composition of this embodiment is: Perilla volatile oil: 1.5%, Ganoderma lucidum powder: 30%, traditional Chinese medicine dry extract: 30%, and other auxiliary materials 38.5%.

[0068] The preparation method of the granule containing perilla oil, the method comprises the following steps:

[0069] 1) Chuanqiong is extracted into volatile oil, and other traditional Chinese medicines are extracted into dry extract;

[0070] 2) Inclusion of volatile oil: Take β-cyclodextrin to prepare a saturated aqueous solution, dissolve the volatile oil of Ligusticum chuanxiong in 50% ethanol with the same weight ratio, and add it to the saturated aqueous solution according to the ratio of perilla volatile oil: β-cyclodextrin = 1:10 , stirred at room temperature for 1.5 hours, stood overnight, removed the supernatant, and vacuum-filtered the lower part of the precipitate, set aside;

[0071] 3) Put the wet perilla oil inclusion compound and Ganoderma lucidum po...

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Abstract

The invention relates to granules of solid traditional Chinese medicine particles and the preparation method of the granules. The granules of solid traditional Chinese medicine particles are prepared by split charging and bagging solid particles. The solid particles are prepared by mixing the following ingredients according to weight percentage: 2 to 10 percent of Chinese medicine volatile oil, 10 to 40 percent of one or more of the Chinese medicine raw powder and zymophyte mycelium powder, 10 to 40 percent of Chinese medicine dry extract, and 10 to 75 percent of other pharmaceutical adjuncts; the Chinese medicine volatile oil and Beta-cyclodextrin are in clathration by adopting the method of saturated aqueous solution, and then solid-liquid separation is performed on clathrate compound after clathration; and the solid particles are made by firstly mixing the clathration compound and then pelletizing. The invention has the following advantages: a volatile oil clathrate compound drying procedure in which more disadvantages exist is eliminated, the loss content of the volatile oil is reduced, the process time is shortened greatly, the retention rate of the volatile oil in finished products of the preparation of Chinese medicine is improved, and the quality and the effectiveness of medicine are ensured.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a granule of Chinese medicine solid particles containing volatile oil and a preparation method thereof. Background technique [0002] The application of volatile oils of traditional Chinese medicines has a long history, and the effectiveness of many volatile oils of traditional Chinese medicines has been known to the ancients. According to the chemical research of modern Chinese medicine, there are a large number of Chinese medicinal materials containing volatile oil, involving almost all types of traditional Chinese medicine, such as mint, Bupleurum, Huoxiang, Curcuma, Chuanqiong, Perilla volatile oil, etc. The properties of the volatile oils of traditional Chinese medicines vary greatly. They are liquid at room temperature, relatively volatile, and unstable in nature. At present, soft capsules or special hard capsules can be selected for solid preparati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 陈建朱方剑潘旖逯振宇刘华本彭晓国林丽萍姚炳兴
Owner ZHEJIANG JOLLY PHARMA