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Preparation method of cordyceps sinensis micropowder lozenges

Cordyceps micropowder and technology of Cordyceps sinensis, applied in the field of Cordyceps micropowder low water content buccal tablets

Inactive Publication Date: 2013-04-17
陈玉龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The micropowder is very viscous after adding water directly, and it is difficult to mix evenly. When using this method, the water content of the micropowder is less than 8% and cannot be pressed into tablets.
In the patent application with the application number 201210128486.8, it is disclosed that firstly, Cordyceps sinensis with a water content of less than 9% is prepared into a nano-powder, and then the nano-powder is added to water with a weight of 2 to 6 times to prepare a homogenate, and then the homogenate After freeze-drying, crush again, mix the original nano-powder for tableting, because it is difficult to directly take samples for moisture determination during the working process of the freeze-drying machine, and the moisture content of the material cannot be accurately controlled through a freeze-drying process, so it has to be dried in the freeze-dried powder The original nano powder is added to adjust the water content, which makes it difficult to accurately control the water content of the material before tableting
In the process of freeze-drying the homogenate into medicinal powder, because the viscous substances in the cells of Cordyceps sinensis are dissolved in water after adding water to the homogenate, during the freeze-drying process, the material is layered in the homogenate during freezing, and the blocky material after freeze-drying The composition of the powder is not uniform, the surface turns black, and the inside is gray. It needs to be pulverized again to get a relatively uniform micropowder, which makes the production process more complicated.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A low-moisture buccal tablet production process of Cordyceps sinensis, the process includes the following steps: preparation of micropowder, preparation of freeze-dried powder, rehydration of freeze-dried powder, tablet compression, and product measurement.

[0032] Preparation of micropowder: take 200g of Cordyceps sinensis with a water content of 10%, and pulverize them at 0°C. During the pulverization process, use liquid nitrogen to refrigerate. It is oxidized in contact with oxygen in the medium to protect the active ingredients from being oxidized and invalidated. Grind Cordyceps sinensis to 0.02~50μm at this temperature by ball mill or other crushing methods. After the crushing is completed, take out the fine powder for later use.

[0033] Preparation of freeze-dried powder: Cordyceps micropowder crushed through the above steps has a diameter of 0.02 to 50 μm and a light brown color. Put the pulverized Cordyceps sinensis micropowder into a freeze-drying machine an...

Embodiment 2

[0040] Preparation of micropowder: select clean Cordyceps sinensis after disinfection and sterilization, and carry out low-temperature water extraction to obtain Cordyceps sinensis with a moisture content of 15%. Put Cordyceps sinensis into a special pulverizer for pulverization, add liquid nitrogen, control the temperature at -196°C, and pulverize for 30 minutes. At this time, the diameter of Cordyceps sinensis micropowder is between 5 and 15 μm. At this time, the color of the Cordyceps micropowder is light brown to gray.

[0041] Preparation of freeze-dried powder: put the Cordyceps micropowder that is crushed to fineness into a freeze dryer, and enter the freeze-drying process. The temperature of the freeze-drying process does not exceed 35°C, the freeze-drying process is 8 hours, and the moisture content is 2%. At this time, the Cordyceps sinensis is freeze-dried Micro powder color is off-white.

[0042] Rehydration of freeze-dried powder: Weigh 1000g of Cordyceps sinensi...

Embodiment 3

[0047] Preparation of micropowder: select clean Cordyceps sinensis after disinfection and sterilization, and drain the water, the water content is 5%. Put the whole Cordyceps sinensis with this content into a special pulverizer for pulverization, add liquid nitrogen, control the temperature at -196°C, and pulverize for 200 minutes. At this time, the diameter of the Cordyceps micropowder is between 0.5 and 0.8 μm. At this time, the color of the Cordyceps micropowder is light brown to gray.

[0048] Preparation of freeze-dried powder: Put the fine powder of Cordyceps sinensis into the freeze dryer and enter the freeze-drying procedure. Micro powder color is off-white.

[0049] Rehydration of freeze-dried powder: Weigh 1000g of Cordyceps sinensis freeze-dried micropowder with a diameter of 0.5~0.8μm and a moisture content of 1.2%. Put the freeze-dried micro-powder of Cordyceps sinensis in an environment of 4°C, calculate the water requirement of 63g, and micronize the sterile w...

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PUM

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Abstract

A preparation method of cordyceps sinensis micropowder lozenges relates to a technology that the cordyceps sinensis is smashed through an ultra-low temperature smashing method and then is frozen and dried to produce the cordyceps sinensis micropowder which serves as the raw material, and then the raw material is rehydrated and pressed to obtain the cordyceps sinensis micropowder lozenges. The method comprises the following steps: first: freezing the cordyceps sinensis with water content not less than 5 percent to be below 0 DEG C, and smashing under the temperature not higher than 0 DEG C; directly freezing and drying the non-defrosting cordyceps sinensis micropowder obtained through smashing, wherein the water content of the micro powder at the moment is not higher than 3 percent (weight); forwards, rehydrating the frozen and dried cordyceps sinensis micropowder; allowing the water for rehydration to be subjected to ultrasonic atomization so as to obtain water mist which is input into the frozen and dried micro powder; meanwhile, stirring the frozen and dried micro powder so as to allow the water content to be raised to 4-20 percent (weight), and obtaining the rehydrated micro powder with the water percent of 4-20 percent (weight); and tabletting the micro powder so as to obtain the cordyceps sinensis micropowder lozenges with the water content not high than 20 percent (weight). The cordyceps sinensis micropowder with water content lower than 8 percent can be directly pressed into the lozenges with uniform water content, and the method for controlling the water content is simple and precise.

Description

technical field [0001] The invention relates to a technique for preparing a micropowder of Cordyceps sinensis with low water content by using Cordyceps micropowder obtained after ultralow temperature pulverization and freeze-drying as a raw material, rehydrating and pressing into tablets. It belongs to the scope of medicine, food and health products. Background technique [0002] Cordyceps sinensis (Cordyceps sinensis) It is a precious traditional Chinese medicine with a history of thousands of years in China. Modern medical research shows that Cordyceps sinensis has various effects such as regulating immune system function, anti-tumor, and anti-fatigue. The active ingredients in it, such as polysaccharides containing protein subunits, and various proteins and enzymes with anti-cancer, anti-tumor and immune-initiating abilities, will be hydrolyzed and destroyed under excessively high temperature conditions. This makes the traditional way of utilizing Cordyceps sinensis in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A23L1/28A23L1/29A61P35/00A61P37/02A61P39/00A23L33/00
Inventor 陈玉龙于同雷王利明王振吉罗小琴
Owner 陈玉龙
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