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A kind of fullerene complex and preparation method thereof

A fullerene complex and fullerene technology, applied in the field of compounds, can solve the problems of poor biocompatibility of fullerene, avoid the addition of toxic reagents, improve biocompatibility, and maintain biological performance.

Active Publication Date: 2015-07-29
SHENZHEN BEAUTYSTAR CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above deficiencies in the prior art, the object of the present invention is to provide a fullerene complex and a preparation method thereof, aiming at solving the problem of poor biocompatibility of existing fullerenes

Method used

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  • A kind of fullerene complex and preparation method thereof
  • A kind of fullerene complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of fullerene ester derivatives:

[0037] The reactor is a round bottom flask and a constant pressure funnel; first in the round bottom flask, 20mg C 60 Dissolve in 10mL toluene to obtain the first mixed solution, then add 14.2mL diethyl bromomalonate to the first mixed solution, stir for 30min; add 13ul DBU (i.e. 1,8-diazepine Bicyclo[5.4.0]undec-7-ene), and add 10ml of toluene to dilute to obtain the second mixed solution, then feed nitrogen into the reactor, such as figure 1 As shown, nitrogen enters from the round-bottomed flask and is discharged from the constant-pressure funnel. After nitrogen gas is introduced for 20 minutes, the constant-pressure funnel is opened and the second mixed solution is slowly added dropwise to the round-bottomed flask below. After the addition, continue to react for two The reaction product was obtained in 1 hour, and the fullerene ester derivatives with different addition numbers were separated after the reaction product w...

Embodiment 2

[0039] Preparation of fullerene complexes:

[0040] 0.5mgC 60 Monoaddition ester derivatives (i.e. fullerene ester derivatives are C 60 Mono-addition product) and 5g PVP (polyvinylpyrrolidone) were dissolved in 100ml ethanol, stirred for 12 hours, evaporated to dryness, redissolved the dried solid in water, heated to evaporate residual ethanol, and dried the obtained product For fullerene complexes. It can be understood that the fullerene di-addition ester derivatives and fullerene tri-addition ester derivatives can be compounded in the same way, or these mixtures with different addition numbers can be compounded together.

Embodiment 3

[0042] 50mgC 60Monoaddition ester derivatives (i.e. fullerene ester derivatives are C 60 Mono-addition product) and 5g PVP (polyvinylpyrrolidone) were dissolved in 100ml ethanol, stirred for 12 hours, evaporated to dryness, redissolved the dried solid in water, heated to evaporate residual ethanol, and dried the obtained product For fullerene complexes.

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Abstract

The invention discloses a fullerene compound and a preparation method thereof. The preparation method comprises the following steps: allowing the fullerene to be subjected to additive reaction to prepare a fullerene ester based derivative; adding the fullerene ester based derivative and water-soluble molecules in an ethanol solution, and uniformly stirring and mixing to obtain a fullerene compound solution; and drying a solvent of the fullerene compound solution to obtain the fullerene compound. The preparation method not only can ensure the molecular structure of the fullerene against damage, but also can maintain the biological performance of the fullerene molecules, greatly improves the biocompatibility of the fullerene compound, avoids the adding of poisonous reagents and ensures the product safety.

Description

technical field [0001] The invention relates to the field of compounds, in particular to a fullerene complex and a preparation method thereof. Background technique [0002] In the prior art, the fullerene complex is generally obtained through the chloroform solution of PVP and C 60 The toluene solution was mixed and stirred evenly, and then the solvent was removed to obtain a fullerene complex. In order to reduce the harm caused by the organic reagent chloroform in the aforementioned patent, the chloroform was changed to ethanol. But, the improved method still fails to reduce the damage that the residue of toluene may bring to the human body. [0003] The problem to be solved by the above method is the solubility problem of fullerene itself, because fullerene molecules can only be dissolved in some aromatic solvents, but aromatic solvents are extremely unsuitable for biological applications, so, now A series of methods are used in the prior art to realize the biological ap...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/753C07C67/347
CPCY02P20/54
Inventor 李慧陈寿王春儒居学成
Owner SHENZHEN BEAUTYSTAR CO LTD
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