Isonicotinic acid ester and preparation method thereof

Abstract

The invention discloses isonicotinic acid ester and a preparation method thereof. The method comprises the following steps that isonicotinic acid, alcohols and a solid acid catalyst react at 120-280 DEG C for 8-18h; water generated in a reaction process is separated by a water separator in the reaction process; a mixture after reaction is subjected to filtering, alkaline washing, water washing and reduced pressure distillation; and then isonicotinic acid ester is obtained. The mass ratio of isonicotinic acid and alcohols is 1:(1-3) (mole / mole); solid acid is stannous oxalate, SO4<2-> / ZrO2-Al2O3 or SO4<2-> / SnO2-Al2O3; and the dosage of the solid acid catalyst is 2-8% of the total mass of isonicotinic acid and alcohols. The method is mild in reaction condition and high in yield; solid acid serves as the catalyst and can be reused; equipment is not corroded; and the equipment investment and operating cost are low.

Description

technical field [0001] The invention relates to a novel isonicotinate compound and a preparation method thereof, in particular to a method for preparing isonicotinate by using solid acid as a catalyst. Background technique [0002] Isonicotinate, the solution is brownish red or brown transparent, has no irritating smell, is not easy to oxidize, does not change color, has good stability, and has good emollient, extensibility and permeability. It is a non-toxic, non-irritating, Nonionic surfactant that does not produce allergic reactions. [0003] The skin has a good absorption of isonicotinate, and it can be in close contact with the hair follicles in the cortex, penetrate deep into the cortex, and bring the active components into it, so as to fully exert the effect of the active ingredients. Adding isonicotinate to cosmetics (amount of 2% to 5%) can make the product evenly spread on the skin, making the skin feel smooth but not greasy, and it is an excellent emollient; addi...

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Problems solved by technology

[0004] At present, there is no manufacturer producing isonicotinate in my country, and most foreign manufacturers use concentrated sulfuric acid as a catalyst. Although concentrated sulfuric acid has ideal catalytic activity as an esterification catalyst, it has the following disadvantages: (1) concentrated sulfuric acid is strong in acidity, and the production process The corrosion of the equipment in the middle is serious, resulting in frequent equipment replacement and increased production costs; (2) concentrated sulfuric acid has strong oxidative properties, resulting in the reaction of alcohol and water to form ether and coke, which affects product quality; (3) a large amount of waste acid, Wastewater pollutes the environment; (4) Concentrated sulfuric acid cannot be recycled as a catalyst, which increases the production cost accordingly; (5) Concentrated sulfuric acid is not easy to separate from the product, the post-treatment process is complicated, and the product cost increases

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