Novel amoxicillin sodium and clavulanate potassium compound and pharmaceutical composition thereof

Abstract

The invention discloses a novel amoxicillin sodium compound. The purity of the amoxicillin sodium compound is more than 99.5%. Meanwhile, the invention also discloses a pharmaceutical composition of an amoxicillin sodium and clavulanate potassium compound. The pharmaceutical composition comprises the following components in parts by weight: 200-400 parts of amoxicillin sodium, 20-36 parts of potassium clavulanate, 1-18 parts of propyl cellulose and 0.2-8 parts of collagen. According to the pharmaceutical composition of the amoxicillin sodium and potassium clavulanate compound, a synergistic effect is generated between propyl cellulose and collagen, so that a slow-release period of an amoxicillin sodium and potassium clavulanate formulation reaches as long as 24 hours, the amoxicillin sodium and potassium clavulanate formulation can be administered once one or two days, thus a patient takes medicine conveniently.

Description

technical field [0001] The present invention relates to a kind of amoxicillin sodium compound and its pharmaceutical composition, especially a kind of amoxicillin sodium compound and its pharmaceutical composition with clavulanate potassium compound. Background technique [0002] Amoxicillin is a broad-spectrum semi-synthetic penicillin, which has a strong ability to penetrate bacterial cell walls. By inhibiting bacterial glycosidase, the synthesis of bacterial cell walls is hindered, and spheroids are rapidly formed to rupture, dissolve and die. It is a widely used clinical drug. Effective drug for the treatment of infections caused by Gram-negative and Gram-positive bacteria. Amoxicillin is an oral raw material drug, which is characterized by strong bactericidal power, low toxicity, and good inhibitory effect on Escherichia coli and Proteus. [0003] The amoxicillin compound in the existing product contains many types and quantities of impurities, which seriously affects ...

AI Technical Summary

Problems solved by technology

[0006] Amoxicillin is a drug with a short half-life. Generally, it needs to be administered at intervals of about 6 hours, which brings inconvenience to patients. At the same time, due to factors such as sleep time affecting the dosing interval, it affects the steady-state blood concentration of the drug. , thus affecting the efficacy of the

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