In vivo small animal fluorescent molecular tomography imaging system and method

Abstract

The invention discloses an in vivo small animal fluorescent molecular tomography imaging system and method; the system comprises a near infrared laser, a beam expander, an electric control rotary table, an object to be imaged, a narrowband filter plate, a charge-coupled device (CCD) camera, an X-ray emitter, an X-ray detector and a computer; the CDD camera and the narrowband filter plate are fixedly arranged in a direction which is in parallel with an excitation light source; the excitation light source, the object to be imaged, the CCD camera and the narrowband filter plate are arranged on a same straight line; the X-ray emitter and the detector are arranged on a direction which is vertical to the excitation light source; the X-ray emitter, the object to be imaged and the X-ray detector are arranged on a same straight line; and the computer is connected with the CCD camera, the X-ray emitter and the electric control rotary table. According to the method, the multi-modal information fusion of an in vivo small animal is realized, and the method has the advantages of simple operation process and short data acquisition time.

Description

technical field [0001] The invention belongs to the field of electronic technology, and relates to an in vivo small animal fluorescence molecular tomography system and method, in particular to an in vivo small animal fluorescence molecular tomography system and method based on a surface excitation light source. Background technique [0002] At present, the existing in vivo small animal fluorescence tomography devices mostly use point excitation light sources to excite fluorescent dyes. The disadvantage is that point excitation cannot ensure that the fluorescent dyes in the object to be imaged are fully excited, and the fluorescent dyes are not completely excited. It will lead to inaccurate collected fluorescence data, low signal-to-noise ratio of the obtained signal image, and inaccurate three-dimensional reconstruction of fluorescence data. On the other hand, in order to obtain more useful fluorescence data, multi-angle and multi-point excitation can be adopted, but the dat...

AI Technical Summary

Problems solved by technology

[0002] At present, the existing in vivo small animal fluorescence tomography devices mostly use point excitation light sources to excite fluorescent dyes. The disadvantage is that point excitation cannot ensure that the fluorescent dyes in the object to be imaged are fully excited, and the fluorescent dyes are not completely excited. It will lead to inaccurate collected fluorescence data, low signal-to-noise ratio of the obtained signal image, and inaccurate three-dimensional reconstruction of fluorescence data.

The disadvantage of this patent application is that because the point excitation light source is used, the fluorescence target is not fully excited, and the signal-to-noise ratio of the obtained fluorescence image is low, which affects the image quality of fluorescence imaging

In addition, because only a single molecular-specific imaging is obtained, and the three-dimensional structure imaging of the object to be imaged is not obtained, the spatial information of the marked part of the object to be imaged is lost, and complete biological feature information cannot be expressed.

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