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Pharmaceutical composite preparation of water-soluble vitamin for injection and fat-soluble vitamin injection

A fat-soluble vitamin and water-soluble vitamin technology, applied in the field of medicine, can solve the problems of incomplete vitamin content supplementation, difficulty in achieving comprehensive parenteral nutrition supplementation, and inability to fully meet clinical requirements, etc.

Inactive Publication Date: 2013-05-08
杭州长典老一元健康管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after all the above-mentioned solvents are dissolved and infused, the supplementation of vitamin content in the human body is not perfect, and it is difficult to achieve a comprehensive supplement of parenteral nutrition, so that it cannot fully meet the clinical requirements.

Method used

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  • Pharmaceutical composite preparation of water-soluble vitamin for injection and fat-soluble vitamin injection
  • Pharmaceutical composite preparation of water-soluble vitamin for injection and fat-soluble vitamin injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 2.8~3.4g of thiamine nitrate, 4.4~5.4g of riboflavin sodium phosphate, 36~44g of nicotinamide, 4.4~5.4g of pyridoxine hydrochloride, 14.8~18.1g of sodium pantothenate, 102~124g of sodium vitamin C, and Vitamin 54~66mg, folic acid 0.36~0.44g, vitamin B 12 4.5~6.0mg, 260~345g of glycine, 0.4~0.6g of methyl p-hydroxybenzoate, 0.4~0.6g of disodium ethylenediaminetetraacetate are mixed into powder, added with freeze-drying protective agent and other auxiliary materials for freeze-drying, and packed into 1000 bottles, just squeeze the cap.

[0018] Weigh vitamin A palmitate 181.5mg (330,000 units), vitamin D 2 0.5mg (20,000 units), vitamin E910mg, vitamin K 1 15mg and excipients soybean oil (for injection) 100g, lecithin (for injection) 12g glycerin 22g and appropriate amount of water for injection to make 1000ml fat-soluble vitamin injection (II), filter, and pour in 10ml / bottle Sealed, sterilized, and packaged together with 1 fat-soluble vitamin injection (II) (spe...

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Abstract

The invention discloses a pharmaceutical composite preparation of a water-soluble vitamin for injection and a fat-soluble vitamin injection, which belongs to the technical field of medicines. The pharmaceutical composite preparation is prepared from the water-soluble vitamin for injection and the fat-soluble vitamin injection (II). Investigation is carried out on solubility, quality stability of a hydrolysis solution and clinical effects of the preparation at different temperatures, and results show that the pharmaceutical composite preparation has better solubility, stable quality and accurate clinical effects and has obvious advantages in clinical usage.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical combination preparation of water-soluble vitamin / fat-soluble vitamin injection (II) for injection. Background technique [0002] Vitamins are a class of trace low molecular organic compounds necessary to maintain the body's life activities. There are many types of vitamins with different chemical structures. Physiologically, they are neither the main raw materials for various tissues nor the energy source in the body. However, they play a very important role in the reaction of energy production and in the process of regulating the body's substance metabolism. role. According to the solubility properties of vitamins, they are divided into two categories: water-soluble and fat-soluble. [0003] Water-soluble vitamins include vitamins C and B. As a component of dozens of coenzymes in the body, they are essential for enzymes that catalyze carbohydrate, lipid and p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/675A61K31/592A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/23A61K31/198A61K31/197A61K31/122A61P3/02
Inventor 傅苗青历达中陈宇东胡国胜
Owner 杭州长典老一元健康管理有限公司
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