Silver-catalyzed synthesis of bis-heterocyclic molecules and bis-heterocyclic molecules with fluorescence activity

Abstract

The invention discloses a synthesis method of bis-heterocyclic molecules and a series of fluorescence functional molecules with a novel bis-heterocyclic structure. Under the action of a catalyst silver fluoride, an additive copper acetate and an additive silver fluoride, oxazole, thiazole, imidazole, or a derivative of them can undergo a cross-coupling reaction so as to obtain new bis-heterocyclic molecules. The compounds have significant fluorescence activity. The synthesis reaction involved in the invention has the characteristics of easily available raw materials, and simple and efficient operation.

Description

technical field [0001] The invention relates to a synthesis method of a biheterocyclic molecule and a novel structural biheterocyclic fluorescent molecule. Background technique [0002] Organic biheterocyclic molecules, especially oxazole, thiazole, and imidazole compounds and their derivatives are widely used in the field of medicine and photoelectric functional materials. The traditional method of synthesizing such compounds is to prepare one heterocyclic molecule as its halide, prepare the other heterocyclic molecule as the corresponding organometallic compound, and then obtain the corresponding biheterocyclic compound by transition metal-catalyzed cross-coupling. This method requires pre-conversion of heterocyclic molecules into corresponding active species, such as halides and organometallic compounds, and the experimental operation is tedious. In recent years, it has been reported in the literature that the C-H bond of two heterocyclic molecules can be directly activa...

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Problems solved by technology

Owing to having used the palladium catalyst of 10mol% in the reaction, the AgF of 200mol% and the Cu(OAc) of 200mol% 2 As an additive, so the synthesis cost is high

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