The preparation and quality control method of high-purity dihedral chlorinated

A technology of chlorinated cinnamon and chlorinated cinnamon, applied in the direction of measuring devices, organic chemistry, instruments, etc., can solve the problem of not being able to meet the requirements of high-purity chlorinated chlorinated chemical reference materials, and the purity and quality control of chlorinated limpets Methods, high production costs and other issues, to achieve the effect of reasonable design, quality assurance, and short production cycle
CN103087070BInactive Publication Date: 2015-08-26广西新桂环保科技集团有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
广西新桂环保科技集团有限公司
Publication Date
2015-08-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method for high-purity nitidine chloride as well as a quality control method of high-purity nitidine chloride. The preparation method is characterized by comprising the following steps of: crushing radix zanthoxyli roots, heating up, refluxing and extracting by using acid alcohol; repeatedly grinding alcohol extract by chloroform; dissolving the obtained precipitates by using methanol, adjusting pH of the solution by using hydrochloric acid, and obtaining nitidine chloride coarse crystals by recrystallization; carrying out recrystallization by using methanol for further improving the purity; preparing by using reverse phase silica gel C-18 and separating by using high-performance liquid chromatography; detecting every part of collected eluant by utilizing an analysis type high performance liquid chromatograph; combining nitidine chloride components with the same retention time, and purity of 90%-98% and more than 98%; concentrating under reduced pressure to obtain nitidine chloride components with purity of 90%-98% and nitidine chloride components with purity bigger than 98%; and carrying out quality control by adopting a thin-layer chromatographic analysis method and a liquid-phase chromatographic analysis method. According to the preparation method disclosed by the invention, not only can the purity of the nitidine chloride be improved, but also the production cost can be reduced.
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Description

technical field

[0001] The invention relates to the field of natural medicines, in particular to a preparation and quality control method of high-purity cinnamon chloride. Background technique

[0002] Zanthoxylum nitidum (Roxb.) DC., the dry root of Zanthoxylum nitidum (Roxb.) DC., belongs to the dry root of Rutaceae Zanthoxylum nitidum. One, it has good effects of promoting qi and relieving pain, promoting blood circulation and removing blood stasis, dispelling wind and dredging collaterals. It is the first choice of commonly used drugs by medical experts, and is widely used in traditional Chinese medicine prescriptions, Chinese patent medicines and fine chemical products. In recent years, the annual demand has been increasing. Products using LMZ herbs as raw materials include nationally famous brands "LMZ TCM Toothpaste", "Sanjiu Weitai", "Jinji Capsule", "Compound LMZ Lozenges", "LMZ Zhen Pain Tablets", "Gushui", "Zhonghua Dieda Pills", "Huoluo Zhitong Pills" and many o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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