Micro-needle roller device

A roller and micro-needle technology, applied in the fields of medicine and beauty, can solve the problems such as the structure and use of the painless micro-needle roller device that have not yet been found, and achieve the effect of significant social benefits.

Inactive Publication Date: 2013-05-29
SHANGHAI SEVENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0097] According to literature search, so far, no newer reports on painless micro-needle roller device products and their structures and uses have been found.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0167] Example 1. Research on the relationship between microneedle application strength and depth

[0168] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0169] Eight pieces of isolated nude mouse back skin were treated with a modified microneedle roller device (needle length 500 μm). The force used is 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20N, and the force is controlled by an electronic balance. Then stain with methylene blue solution for 2 minutes, and wash away the dye solution with water. After wiping off the water and residual dye with a dry cotton ball, cut the above skin into small pieces of 1 cm × 0.5 cm, then immerse the tissue in OCT liquid and freeze it at low temperature in liquid nitrogen for overnight. The length of the pinhole and record. Experimental results:

[0170] Table 1. Research on the relationship between the strength and depth of microneedle use

[0171]

[0172] After the modification of the micr...

Embodiment 2

[0173] Example 2. Study on the Effectiveness of Transdermal Administration (Franz Diffusion Cell Method)

[0174] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0175] Take 2 pieces of nude mouse skin, remove the subcutaneous tissue, and rinse with normal saline. The blank group was not treated with microneedles, and the experimental group was treated with modified microneedle rollers. The skin of the blank group and the experimental group was fixed between the Franz administration chamber and the receiving chamber, the stratum corneum faced the administration chamber, and the effective penetration area was 0.85cm 2 . Add hydroalcoholic solution (isopropanol: normal saline = 1:1) into the receiving chamber until it is in close contact with the skin (4ml), remove air bubbles, place in a constant temperature water bath at (37.0±0.5)°C, (200±1)r / min constant speed electromagnetic stirring. Apply 0.2g retinoic acid cream on ...

Embodiment 3

[0180] Embodiment 3, skin irritation research

[0181] Utilize the device of technical scheme of the present invention, specific content is as follows:

[0182] After nude mice were anesthetized, they were treated with a modified microneedle roller, and the nude mice were killed 3 days after the treatment. The skin tissue administered percutaneously was fixed with 10% formaldehyde (diluted in PBS), dehydrated with ethanol, embedded in paraffin, sectioned (5 μm), and mounted On the glass slide, stained with HE, observe the tissue reaction and inflammatory cells under the microscope, and take pictures. The control group was not treated with microneedling. HE staining process:

[0183] ① Stain with hematoxylin solution for 5-15 minutes.

[0184] ②Rinse with running water for 3~5 minutes.

[0185] ③The 0.5~1% hydrochloric acid alcohol solution differentiates for a few seconds.

[0186] ④Rinse with running water, and the weak alkaline aqueous solution will appear blue for 1min...

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PUM

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Abstract

The invention relates to a skin beauty and skin drug delivery device and a purpose of the skin beauty and skin drug delivery device. A protection cover is additionally arranged on the device and a movable connecting mode of multidirectional sliding or multi-angle movable embedding is adopted by a handle and a support of a fixed support so that transdermal drug delivery, transdermal absorption and system slow release are improved. A rolling needle is capable of producing a large amount of micro-tubes at a short time so that drugs, beauty products and the like can directly penetrate through epidermal layer cells and corium layer cells of the skin. A wound in the epidermal layer is small and healing of the wound is rapid so that possibility of bacterial infection is obviously reduced, the skin is not hardened or skin cells are not contracted, epidermal tissue does not become thinner and the device is capable of being reused. The device can further be used for massaging the skin on the head so that hair can be stimulated to grow. The device is simple in manufacturing technology, low in cost and side effect, obvious in effect, good in controllability, convenient to use, capable of being controlled by simple training, strong in practicality, capable of being directly used in daily life, particularly suitable for mass production and business application for industries and businesses of medicine, beauty and the like and remarkable in benefit.

Description

technical field [0001] The present invention relates to technical fields such as medicine and cosmetology, in particular to a painless drug delivery device for transdermal administration of medicines and beauty products, and its structure and application, and more specifically to a device for transdermal drug delivery. A painless micro-needle roller device for fast transdermal absorption or sustained release of medicine or beauty products and its structure and application. Background technique [0002] (1) Research overview of microneedle rollers [0003] 1 Overview [0004] In the 21st century, the medical field is facing a new problem in the field of medicine: how to correctly deliver the drug to the site where it needs to be treated, so as to maximize the efficacy of the drug. The beauty industry is also facing the same problem. Why are some high-tech nanotechnology, first-class raw materials and expensive beauty creams and beauty creams after use, the effect is not as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023
Inventor 张立超刁枢胡静吴志宏张娟娟
Owner SHANGHAI SEVENTH PEOPLES HOSPITAL
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