Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof

A dry suspension, chlorpheniramine acid technology, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc. High utilization, easy to mix evenly, fast absorption effect

Active Publication Date: 2014-07-30
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is in order to solve the shortcoming of poor water solubility and low bioavailability of existing compound phenol-mamemin, and has invented compound phenol-mamemin dry suspension

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 compound phenol mamemin dry suspension

[0032] Active ingredient 50g

[0033] Mannitol 700g

[0034] Aspartame 50g

[0035] Methylcellulose: dextran (3:2 by weight) 50g

[0036] Anhydrous disodium hydrogen phosphate 10g

[0037] The active ingredients are composed of paracetamol, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate; by weight ratio, paracetamol: pseudoephedrine hydrochloride: dextromethorphan hydrobromide: Chlorpheniramine maleate=16:1.5:0.5:0.1.

[0038] The preparation method is as follows:

[0039] (1) Accurately weigh the active ingredient of the prescription amount and pass through an 80-mesh sieve;

[0040] (2) Precisely weigh mannitol, aspartame, methylcellulose, dextran, and anhydrous disodium hydrogen phosphate respectively, pass through an 80-mesh sieve, and mix uniformly in equal increments;

[0041] (3) Steps (1) and (2) are mixed in equal increments to obtain a mix...

Embodiment 2

[0043] The preparation of embodiment 2 compound phenol mamemin dry suspension

[0044] Active ingredient 50g

[0045] Mannitol 700g

[0046] Aspartame 50g

[0047] Methylcellulose: dextran (1:1 by weight) 50g

[0048] Anhydrous disodium hydrogen phosphate 10g

[0049] The active ingredients are composed of paracetamol, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate; by weight ratio, paracetamol: pseudoephedrine hydrochloride: dextromethorphan hydrobromide: Chlorpheniramine maleate=16:1.5:0.5:0.1.

[0050] The preparation method is the same as in Example 1.

Embodiment 3

[0051] Example 3 The preparation of compound phenol mamemin dry suspension

[0052] Active ingredient 50g

[0053] Mannitol 700g

[0054] Aspartame 50g

[0055] Methylcellulose: dextran (3:1 by weight) 50g

[0056] Anhydrous disodium hydrogen phosphate 10g

[0057] The active ingredients are composed of paracetamol, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate; by weight ratio, paracetamol: pseudoephedrine hydrochloride: dextromethorphan hydrobromide: Chlorpheniramine maleate=16:1.5:0.5:0.1.

[0058] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention discloses a compound pseudoe-phedrine hydro-chloride dry suspension and a preparation method of the compound psedoe-phedrine hydro-chloride dry suspension. The compound psedoe-phedrine hydro-chloride dry suspension comprises 40-100 parts of active ingredients, 600-2200 parts of filler, 50-200 parts of flavoring agents, 40-100 parts of suspending agents and 10-40 parts of flocculating agents, wherein the active ingredients are composed of acetaminophen, pseudoephedrine hydrochloride, dextromethorphan hydrobromide and chlorpheniramine maleate. The compound pseudoe-phedrine hydro-chloride dry suspension is even in particle distribution, good in stability, large in distribution area in a stomach and intestines, quick in absorption, high in bioavailability, quick in effect producing, and superior to a compound pseudoe-phedrine hydro-chloride premix in pharmaceutical effect.

Description

technical field [0001] The invention relates to a dry suspension, in particular to a compound phenamine dry suspension and a preparation method thereof, and belongs to the field of compound phenamine preparations. Background technique [0002] Dry suspensions refer to insoluble drugs and suitable excipients made into powders or granules, which can be dispersed into suspensions for oral administration by adding water and shaking before use. The dry suspension belongs to the suspension. After adding water to disperse, it should meet the quality requirements of the suspension. The particles in the suspension should be uniformly dispersed and should not be weighed quickly. It should be quickly redispersed. In addition to the effectiveness and chemical stability of the ideal suspension (mainly depends on the nature of the main drug), the ideal suspension should also (1) settle slowly, and can be redispersed by shaking gently after settling; The size should remain unchanged in l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K31/4402A61K31/167A61K31/137A61K47/38A61K47/36A61K9/14A61P29/00A61P11/02A61P11/14
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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