A method for preparing multiple active substances from ginkgo biloba

Abstract

A method for preparing multiple active substances from ginkgo leaves, which belongs to the production method of chemical substances or medicines. The invention adopts strong polar or polar macroporous adsorption resin for separation, and solves the problem of high ginkgolic acid in the existing preparation of ginkgo extracts. Problems, and solve the existing extraction and preparation of ginkgo active substances consume a large amount of organic solvents, causing environmental pollution; or the use of more complex separation technology is difficult to scale up production; or extraction efficiency is not high, raw material utilization is low and other problems. Ginkgo polysaccharides, ginkgo extracts, total ginkgo flavonoids, total ginkgo lactones, ginkgo lactone A, B, C monomers and other active substances can be obtained at the same time. The project technology includes raw material pretreatment steps, extraction steps, polysaccharide precipitation steps, macroporous resin separation steps, silica gel dry column separation steps, reverse phase chromatography purification steps and crystallization steps, etc., which saves production costs and improves production efficiency. It is simple and easy to expand to industrial production, and can greatly improve the utilization rate of raw materials.

Description

technical field [0001] The invention belongs to a manufacturing method of chemical substances or medicines, and in particular relates to a method for obtaining various active substances by extracting, separating and purifying ginkgo leaves as raw materials. Background technique [0002] Ginkgoaceae plants widely existed in Asia, Africa, Europe, South America and Australia 200 million years ago. Almost all over the earth's surface. Due to the great changes in the earth during the Tertiary and Quaternary periods, most of the Ginkgoaceae plants became extinct, and only one species of Ginkgo biloba survived, so it is called a "living fossil" plant. Ginkgo is a unique precious tree species in my country, especially in the south of the Yangtze River and Taiwan Province, accounting for more than 70% of the world's total ginkgo resources. With the excavation and development of the comprehensive value of medicinal and health care components in Ginkgo biloba, the systematic research...

AI Technical Summary

Problems solved by technology

[0006] The invention provides a method for preparing various active substances from ginkgo leaves, which is separated by strong polarity or polar macroporous adsorption resin, solves the problem of high ginkgolic acid in the existing preparation of ginkgo extract, and solves the problem of existing extraction and The preparation of ginkgo active substances consumes a large amount of organic solvents, causing environmental pollution; or it is difficult to scale up production by using more complicated separation techniques; or the extraction efficiency is not high, and the utilization rate of raw materials is low, etc.