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Risperidone film-like preparation

A technology of risperidone film and risperidone, which is applied in sheet delivery, medical preparations with inactive ingredients, nervous system diseases, etc. Increase interest and increase the effect of beauty

Inactive Publication Date: 2013-06-12
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acidic agent and alkaline agent in the effervescent agent react during the pulping process and cannot remain in the film at the same time
2) When preparing the compound film, due to the different physical and chemical properties of the active ingredients in the compound, the suitable prescription and process are different, and sometimes they will affect each other
For example, in a compound composed of A and B, acidic auxiliary materials can enhance the stability of substance A, but affect the solubility of substance B, making it difficult for B to disperse evenly during the pulping process

Method used

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  • Risperidone film-like preparation
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  • Risperidone film-like preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] 1) Take 30g of risperidone and add 600ml of distilled water, stir and disperse evenly, then add 20g of citric acid, 20g of sucralose and 0.2g of brilliant blue in turn while stirring, and finally add 130g of PEO, stir evenly, pass through an 80-mesh sieve to remove insoluble material, vacuum defoaming. Obtain slurry A.

[0095] 2) Take 30g of risperidone and add 600ml of distilled water, stir and disperse evenly, then add 20g of sodium carbonate, 20g of sucralose and 0.2g of brilliant blue in sequence while stirring, and finally add 130g of PEO, stir evenly, pass through an 80-mesh sieve to remove insoluble material, vacuum defoaming. Obtain slurry B.

[0096] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dryer, coat with a coating blade, spread the film on a stainless steel belt, and dry at 50°C for 15 mi...

Embodiment 2

[0102]1) Take 20g of risperidone and add 600ml of distilled water, stir and disperse evenly, then add 10g of PEG4000, 10g of fumaric acid, 0.2g of BHT, 10g of sodium saccharin and 10g of titanium dioxide in turn while stirring, and finally add 40g of PVP and 100g of HPMC, stir evenly, 80-mesh sieve to remove insoluble matter and vacuum defoaming. Obtain slurry A.

[0103] 2) Take 20g of risperidone and add 600ml of distilled water, stir and disperse evenly, then add 10g of PEG4000, 10g of potassium bicarbonate, 0.2g of BHT, 10g of sodium saccharin and 10g of titanium dioxide in turn while stirring, and finally add 40g of PVP and 100g of HPMC, stir evenly, 80-mesh sieve to remove insoluble matter and vacuum defoaming. Obtain slurry B.

[0104] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dryer, coat with a coatin...

Embodiment 3

[0110] 1) Take 10g of risperidone and add 500ml of distilled water, stir and disperse evenly, then add 10g of aspartame, 20g of cyclamate, 6g of glycerin, 0.2g of EDTA, 0.2g of lemon yellow and 4g of tartaric acid while stirring, and finally add 100g of HPC and malt Dextrin 50g, stir well, pass through 80 mesh sieve, remove insoluble matter, vacuum defoaming. Obtain slurry A.

[0111] 2) Take 10g of risperidone and add 500ml of distilled water, stir and disperse evenly, then add 10g of aspartame, 20g of cyclamate, 6g of glycerin, 0.2g of EDTA, 0.2g of tartrazine and 4g of potassium carbonate while stirring, and finally add 100g of HPC and Maltodextrin 50g, stir evenly, pass through 80 mesh sieve, remove insoluble matter, vacuum defoaming. Obtain slurry B.

[0112] Add the slurry A and the slurry B into the dosing tank, which is composed of two parallel small tanks with a width of 1.2 cm, and the width of the partition between the small tanks is 0.1 cm. Start the coating dry...

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Abstract

The invention provides a risperidone film-like preparation, comprising a strip film belt and a treatment effective dose of an active medicine loratadine loaded on the strip film belt, wherein the strip film belt comprises an acidic strip film belt and an alkaline strip film belt, the acidic strip film belt and the alkaline strip film belt are connected to form one body, the acidic strip film belt uses a highly water-soluble polymer film forming material as a main body and contains 1 to 20% of an acidic agent on the basis of the weight of the acidic strip film belt, and the alkaline strip film belt uses the highly water-soluble polymer film forming material as a main body and contains 1 to 20% by weight of an alkaline agent on the basis of the weight of the alkaline strip film belt. In the presence of water, the risperidone film-like preparation provided by the invention becomes an effervescent film, generates considerable bubbles, paralyzes olfactory sensation of people so as to mask odor and is accelerated in dissolving-out.

Description

technical field [0001] The invention relates to a risperidone preparation, in particular to a drug film preparation containing risperidone. Background technique [0002] Risperidone is a derivative of benzisoxazole, which is a new generation of antipsychotics. It is a selective monoaminergic antagonist with unique properties, unlike the serotonergic 5-HT 2 D receptors and dopamine 2 The receptor has a high affinity. For the treatment of acute and chronic schizophrenia and the obvious positive symptoms (such as hallucinations, hallucinations, disorganized thinking, hostility, suspicion) and obvious negative symptoms (such as unresponsiveness, emotional and social apathy, few words). It may also reduce affective symptoms (eg, depression, guilt, anxiety) associated with schizophrenia. For patients who are effective in the acute phase of treatment, their clinical efficacy can continue to be exerted in the maintenance phase of treatment. The risperidone is prepared into a f...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/519A61K47/38A61K47/36A61K47/34A61K47/32A61P25/18A61K47/10
Inventor 陈芳侯惠民杨柳榴
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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