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Extraction technology of Lemai particle crude medicines

An extraction process and a technology for raw materials, applied in the field of medicine, can solve problems such as large gaps in effective components, low extraction efficiency, unreasonable processes, etc., and achieve the effects of reducing raw material costs, reducing paste yield, and reducing production costs.

Inactive Publication Date: 2013-06-12
SICHUAN CHUANDA WEST CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The outstanding problems of these extraction methods are: ① low extraction efficiency and long time; ② large gap between the extracted active ingredients and the target value
But the extraction comes first, the concentration comes later, and the extraction is carried out under normal pressure and high temperature, most of the heat-sensitive components have been destroyed, thus forming an extremely unreasonable process inversion problem

Method used

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  • Extraction technology of Lemai particle crude medicines
  • Extraction technology of Lemai particle crude medicines
  • Extraction technology of Lemai particle crude medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 The extraction process of Lemai granule bulk drug of the present invention

[0024] Weigh 160g of salvia miltiorrhiza, 80g of chuanxiong, 80g of safflower, 80g of red peony, 40g of Cyperus cyperi, 40g of woody fragrance, and 20g of hawthorn. Put the above-mentioned crude drug into a decompression extraction tank, add water 10 times the weight of the raw material, soak for 2 hours, then heat to 80°C, then evacuate to boiling, keep boiling for 3 times, each time for 1 hour, combined extraction liquid.

Embodiment 2

[0025] Embodiment 2 The research of Lemai granule raw material extraction process of the present invention

[0026] 1. Determination of salvianolic acid B, ferulic acid and paeoniflorin in medicinal materials

[0027] Referring to the relevant content and methods under the items of Danshen, Chuanxiong, and Chishao in the 2010 edition of "Chinese Pharmacopoeia", the contents of salvianolic acid B, ferulic acid, and paeoniflorin in the medicinal materials used in this experiment were respectively measured.

[0028] 2. Chromatographic conditions for determination

[0029] Stationary phase: LP-C18 (4.6*250mm, 5μm); mobile phase: acetonitrile-0.4% phosphoric acid gradient elution, as shown in the table below. Detection conditions: column temperature 25°C, detection wavelength 235nm, injection volume 10μL.

[0030] Table 1

[0031]

[0032] 3. Determination of dry paste rate

[0033] Take 30mL of the extract and place it in an evaporating dish with constant weight (M 1 ), dr...

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Abstract

The invention provides an extraction technology of Lemai particle crude medicines. The extraction technology comprises the following operation steps: (1) weighing crude medicines by weight proportioning on prescription: 8 parts of radix salviae miltiorrhizae, 4 parts of ligusticum wallichii, 4 parts of radix paeoniae rubra, 4 parts of safflower carthamus, 2 parts of radix aucklandiae, 2 parts of cyperus rotundus and 1 part of hawthorn fruits; and (2) adding the crude medicines weighed in step (1) in an extraction solvent, extracting by decompression, and finally collecting extract. The invention also provides the extract prepared by the technology as well as the applications of the extract. According to the extraction method, the yield of the extract is increased remarkably, the medicine effect activity of the extract is enhanced, the utilization rate of the crude medicines is improved, the material cost is reduced and the extraction technology is applicable to industrial production.

Description

technical field [0001] The invention relates to an extraction process of Lemai granule crude drug, belonging to the field of medicine. Background technique [0002] Lemai granules are refined from the seven herbs of Salvia miltiorrhiza, Chuanxiong, safflower, red peony root, Cyperus cyperi, woody fragrance, and hawthorn according to the ratio of 8:4:4:4:2:2:1. Dissipating blood stasis and dredging channels is commonly used clinically for headache, dizziness, chest pain, and palpitations caused by qi stagnation and blood stasis syndrome; coronary heart disease, angina pectoris, and multiple cerebral infarctions see the above syndromes. It is a variety included in the Pharmacopoeia of the People's Republic of China (Part One), a category B variety in the National Medical Insurance List (2009), and a variety in the basic drug catalog of the new rural cooperative medical care in Shanxi Province. It is exclusively produced by Sichuan Chuanda Huaxi Pharmaceutical Co., Ltd. . [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P9/10
Inventor 刘娅张定堃姚喆施俊辉王欣眉严娜黄晶
Owner SICHUAN CHUANDA WEST CHINA PHARMA