Method for preparing porous hydroxyapatite scaffold via two-step process

A technology of porous hydroxyapatite and hydroxyapatite, which is applied in the field of biomedical materials, can solve the problems of complex process and long preparation cycle, and achieve the effect of low residual content

Inactive Publication Date: 2013-06-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the technology is complicated and the preparation period is long

Method used

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  • Method for preparing porous hydroxyapatite scaffold via two-step process
  • Method for preparing porous hydroxyapatite scaffold via two-step process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Such as figure 1 As shown, this embodiment includes:

[0023] Step 1, weigh hydroxyapatite, PMMA, SDS and ammonium bicarbonate according to the ratio of 8:6:11:3;

[0024] Step 2, putting hydroxyapatite, PMMA and SDS into a glass container, stirring evenly with a machine;

[0025] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:1;

[0026] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0027] Step 6, put in an oven, dry at 70°C, take out the block after drying, and put it in a crucible;

[0028] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 600°C at 2°C / min for 2 hours;

[0029] Step 8, continue to heat up at 2°C / min to 1000°C for 2 hours;

[0030] Step 9, taking out the crucible after cooling with the furnace to obtain a porous hydroxyapatite support.

Embodiment 2

[0032] Step 1, weigh hydroxyapatite, PMMA, SDS and ammonium bicarbonate according to the mass ratio of 8:5:10:2;

[0033] Step 2, put hydroxyapatite, PMMA and SDS into a glass container, and mechanically stir evenly;

[0034] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:0.75;

[0035] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0036] Step 6, put in an oven, dry at 60°C, take out the block after drying, and put it in a crucible;

[0037] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 600°C at 2°C / min for 2 hours;

[0038] Step 8, continue to heat up at 2°C / min to 1300°C for 2 hours;

[0039] Step 9, taking out the crucible after cooling with the furnace to obtain a porous hydroxyapatite support.

Embodiment 3

[0041] Step 1, weigh hydroxyapatite, PMMA, SDS and ammonium bicarbonate according to the ratio of 8:6:11:3;

[0042] Step 2, putting hydroxyapatite, PMMA and SDS into a glass container, stirring evenly with a machine;

[0043] Step 3, dissolving ammonium bicarbonate in ultrapure water at a ratio of 1:1;

[0044] Step 4, drop the ammonium bicarbonate solution into the mixed powder, and stir evenly;

[0045] Step 6, put in an oven, dry at 70°C, take out the block after drying, and put it in a crucible;

[0046] Step 7, put the crucible into a high-temperature heating furnace, and raise the temperature to 400°C at 2°C / min for 2 hours;

[0047] Step 8, continue to heat up at 2°C / min to 1100°C for 2 hours;

[0048] Step 9, taking out the crucible after cooling with the furnace to obtain a porous hydroxyapatite support.

[0049] To sum up, the present invention greatly improves the strength and toughness of the prepared scaffold material through targeted high-temperature sinteri...

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Abstract

The invention relates to a method for preparing a porous hydroxyapatite scaffold via a two-step process, and belongs to the technical field of biomedical materials. The method comprises the following steps: evenly mixing fluoride hydroxyapatite, PMMA (polymethyl methacrylate) and SDS (sodium dodecyl sulfate); dripping an ammonium bicarbonate solution into the mixture and evenly stirring; drying and heating to reach the temperature of 400 to 600 DEG C; carrying out a heat preservation treatment; continuously heating to reach the temperature of 1000 to 1300 DEG C and carrying out the secondary heat preservation; and finally cooling along with a cooling furnace, thereby obtaining the porous hydroxyapatite scaffold. Based on the secondary high-temperature sintering process, the strength and the toughness of the scaffold material are improved. The residual quantity of the PMMA as a foaming agent in the scaffold is very low, so that the usage of a template is avoided; and the existing technological process is simplified greatly. In addition, the method is simple to operate.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a two-step method for preparing a porous hydroxyapatite support. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth, so it has good biological activity and osteoinductivity. Porous hydroxyapatite not only has the characteristics of hydroxyapatite, but also has the excellent properties of porous materials. HAP scaffolds with good biological activity, high strength, and processability are the best choice to replace damaged hard tissues in the human body, so they have attracted much attention from the medical community. [0003] At present, the methods for preparing porous materials include template method, freeze-drying method, foaming method, and adding pore-forming agent. Among them, the preparation process of the template method is simple, and the prepared porous material has uniform pores and good con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12
Inventor 饶群力巩梦安杨洪震
Owner SHANGHAI JIAO TONG UNIV
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