Chitosan oligosaccharide derivative and nano-silver preparation method

A technology of chitosan oligosaccharides and derivatives, which is applied in the medical field and can solve problems such as high production costs, limited use, and high requirements for equipment

Inactive Publication Date: 2013-07-03
HENAN AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the principles of various physical methods are simple, their use is limite

Method used

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  • Chitosan oligosaccharide derivative and nano-silver preparation method
  • Chitosan oligosaccharide derivative and nano-silver preparation method
  • Chitosan oligosaccharide derivative and nano-silver preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The synthesis of embodiment 1 chitosan oligosaccharide derivative

[0045] The synthesis principle of chitosan oligosaccharide derivatives

[0046] The present invention uses low molecular weight (2000~3000) chitosan oligosaccharides and salicylaldehyde under the condition that absolute ethanol is made solvent, has explored chitosan oligosaccharide Schiff base (S-COS) synthetically the most under different conditions respectively Optimum conditions, and its synthesis conditions were optimized to find out the best conditions for the synthesis of chitosan oligosaccharide Schiff base. Then utilize the synthesized chitosan oligosaccharide Schiff base (S-COS) and diethyl phosphite to synthesize chitosan oligosaccharide Schiff base phosphonate (S-COS-P) under the condition of absolute ethanol as solvent and to The synthesis conditions were optimized. Nano-silver was prepared by reducing chitosan oligosaccharide Schiff base (S-COS) and chitosan oligosaccharide Schiff base ph...

Embodiment 2

[0053] Example 2 Preparation of nano silver by reduction of chitosan oligosaccharide derivatives

[0054] Preparation principle

[0055] The preparation method of nano-silver can be divided into chemical reduction method (chemical reduction of silver ion in aqueous or non-aqueous solvent), microemulsion method, template method, electrochemical method, light-induced or photocatalytic reduction method, microwave-assisted or photocatalytic reduction method according to the reaction conditions. Ultrasound-assisted method, radiation reduction method, etc. In this experiment, the chemical reduction method under the protection of the stabilizer was used to prepare, and its absorbance was scanned with a UV-Vis spectrophotometer.

[0056] Spherical silver nanoparticles usually have a strong absorption peak around 410nm, and it is generally believed that this absorption peak is caused by the plasmon resonance of silver nanoparticles. In metal electron theory, the free electrons in met...

Embodiment 21

[0058] Embodiment 2.1: Prepare the carboxymethylcellulose sodium (CMC) solution (1%), AgNO 3 solution (1%), chitosan oligosaccharide phosphonate (S-COS-P) solution (1%), mix carboxymethylcellulose sodium (CMC) solution, AgNO 3 Solution, add a certain amount of reducing agent chitosan oligosaccharide phosphonate at a certain temperature, scan its absorbance with a UV-visible spectrophotometer, and record the change trend of the solution absorption curve with time.

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Abstract

The invention discloses a chitosan oligosaccharide derivative and a nano-silver preparation method. The nano-silver preparation method comprises the following steps of: (1) synthesizing chitosan oligosaccharide Schiff base S-COS; (2) synthesizing chitosan oligosaccharide phosphonate S-COS-P; and (3) preparing the nano-silver by reducing the chitosan oligosaccharide derivative. A method for synthesizing the chitosan oligosaccharide derivative by taking chitosan oligosaccharide as a raw material under the condition of microwave radiation is explored, and the structure of the chitosan oligosaccharide derivative is characterized, the optimum reaction conditions of the chitosan oligosaccharide derivative are explored, and simultaneously, the nano-silver is prepared by reducing the synthesized chitosan oligosaccharide derivative; and the nano-silver preparation method is preliminarily explored, and the structure of the nano-silver is characterized; and the preliminary conclusion of nano-silver preparation is obtained.

Description

technical field [0001] The invention belongs to the field of medical technology, and relates to a preparation method of chitosan oligosaccharide derivatives and nano-silver. Background technique [0002] Due to the wide application of chitosan oligosaccharide derivatives in the food industry, pharmaceutical industry, textile industry, environmental protection industry, agriculture, and cosmetics industry, the demand for chitosan oligosaccharides and their derivatives is very strong at home and abroad. At present, the high-tech products of marine biomaterials prepared by applying chitin and its derivatives are continuously launched in the world, and the number of products has reached more than 500. The derivatives with unique properties have been prepared by chemically modifying and modifying chitin and chitosan. It has become an important topic in today's chemical industry. Due to the insolubility of chitin and the poor solubility of chitosan, its application is limited, es...

Claims

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Application Information

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IPC IPC(8): B22F9/24C08B37/08
Inventor 徐翠莲王彩霞黄元炯樊素芳杨国玉李鑫赵铭钦刘国顺姬小明万峥凯
Owner HENAN AGRICULTURAL UNIVERSITY
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