Liquid preparation for oral administration used in CT colonography, and composition for imaging digestive tract

Abstract

The present invention provides a liquid preparation for oral administration that is capable of reducing the amount of colonic irrigation solution taken during gastrointestinal pretreatment and decreasing the burden on the subject without sacrificing test accuracy and without prolonging the time required for pretreatment, and a composition for gastrointestinal radiography used to prepare the liquid preparation for oral administration. Namely, provided are a liquid preparation for oral administration taken during gastrointestinal imaging by CT colonography that comprises an iodine compound and a water-soluble polymer or saline laxative, wherein 300 mL to 1200 mL are taken on the day before CT colonography in a single administration or divided among several administrations, and a composition for gastrointestinal radiography comprising an iodine compound and a water-soluble polymer or saline laxative, wherein 300 mL to 1200 mL are taken in the form of an aqueous solution, having an iodine content of 3.5 mg / mL to 90 mg / mL prepared by dissolving in water, on the day before CT colonography in a single administration or divided among several administrations.

Description

technical field [0001] The present invention relates to a liquid preparation for oral administration used in pretreatment for CT colonography, and a composition for gastrointestinal imaging used in preparation of the liquid preparation for oral administration. Background technique [0002] With the development of spiral CT and multidetector CT, colon examination using computed tomography (CT) (CT colonography) is becoming more and more popular. In Europe and the United States, colon screening has become more and more popular. CT colonography is to perform CT imaging in the state where the colon lumen is expanded with air after cleaning the feces in the colon, and it is constructed based on the subtle X-ray contrast difference between colon tissue and air, Image information is processed (for example, refer to Patent Document 1). [0003] CT colonography does not require the insertion of an endoscope and barium compared to conventional enema X-ray examinations and colonoscop...

AI Technical Summary

Problems solved by technology

However, when a large amount of oral intestinal cleansing solution is used to reduce residual stool, there is a problem that liquid residue increases

Contrast with the digestive tract tissue cannot be obtained at the site where residual water and intestinal fluid are stored, and cannot form a useful inspection image for diagnosis

In other words, the site where residual water and intestinal fluid are stored becomes an area where no lesion can be detected at all

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