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Cefdinir, citric acid and sodium citrate dry suspension composition

A technology of cefdinir and sodium citrate, which is applied in the direction of medical preparations of non-active ingredients, organic active ingredients, antibacterial drugs, etc., which can solve the inconvenience of patients taking, the bioavailability and stability of cefdinir drugs Low-level problems, to achieve the effect of easy portability, improved bioavailability and stability, and suitable for large-scale production

Active Publication Date: 2013-08-14
XIAN ENCI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the cefdinir drugs produced in China are capsules and dispersible tablets, which are not convenient for patients to take, especially for the elderly, children and other patients who have difficulty swallowing
In addition, because the cefdinir raw material is more insoluble in water, the bioavailability and stability of cefdinir drugs are lower, therefore, how to develop a kind of cefdinir with higher bioavailability and stability and convenient for patients to take Nepalese medicine has become a problem to be solved urgently in this field

Method used

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  • Cefdinir, citric acid and sodium citrate dry suspension composition
  • Cefdinir, citric acid and sodium citrate dry suspension composition
  • Cefdinir, citric acid and sodium citrate dry suspension composition

Examples

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Effect test

preparation Embodiment 1

[0042] Prepare the cefdinir dry suspension of the present embodiment according to the following composition ratio:

[0043] Cefdinir 100g Sucrose 2000g

[0044] Sodium citrate 80g Citric acid 80g

[0045] Strawberry powder flavor 32g 50% (wt) ethanol aqueous solution 190g

[0046] Xanthan gum 20g Micronized silica gel 10g

[0047] Magnesium Stearate 2g

[0048] Step 1, pulverizing sucrose, citric acid and sodium citrate;

[0049] Step 2, passing cefdinir through a 200-mesh sieve, passing sucrose, citric acid, sodium citrate and magnesium stearate through a 100-mesh sieve, passing strawberry powder essence, xanthan gum and micronized silica gel through a 80-mesh sieve;

[0050] Step 3, weigh each component according to the above content, first add sucrose and citric acid into the high-speed mixing granulator and mix for 1min, the mixing speed is 400rpm, and the cutting speed is 3000rpm, then sodium citrate, strawberry powder essence and Add cefdinir, turn on the granulatin...

preparation Embodiment 2

[0054] Prepare the cefdinir dry suspension of the present embodiment according to the following composition ratio:

[0055] Cefdinir 100g Sucrose 2100g

[0056] Sodium citrate 60g Citric acid 60g

[0057] Strawberry powder essence 35g 50% (wt) ethanol aqueous solution 185g

[0058] Xanthan gum 30g Micronized silica gel 8g

[0059] Magnesium Stearate 1.5g

[0060] Step 1, pulverizing sucrose, citric acid and sodium citrate;

[0061] Step 2, passing cefdinir through a 200-mesh sieve, passing sucrose, citric acid, sodium citrate and magnesium stearate through a 100-mesh sieve, passing strawberry powder essence, xanthan gum and micronized silica gel through a 80-mesh sieve;

[0062] Step 3, weigh each component according to the above content, first add sucrose and citric acid into the high-speed mixing granulator and mix for 1min, the mixing speed is 400rpm, and the cutting speed is 3000rpm, then sodium citrate, strawberry powder essence and Add cefdinir, turn on the granulat...

preparation Embodiment 3

[0066] Prepare the cefdinir dry suspension of the present embodiment according to the following composition ratio:

[0067] Cefdinir 100g Sucrose 2100g

[0068] Sodium citrate 90g Citric acid 90g

[0069] Strawberry powder flavor 28g 50% (wt) ethanol aqueous solution 190g

[0070] Xanthan gum 20g Micronized silica gel 10g

[0071] Magnesium Stearate 2g

[0072] Step 1, pulverizing sucrose, citric acid and sodium citrate;

[0073] Step 2, passing cefdinir through a 200-mesh sieve, passing sucrose, citric acid, sodium citrate and magnesium stearate through a 100-mesh sieve, passing strawberry powder essence, xanthan gum and micronized silica gel through a 80-mesh sieve;

[0074] Step 3, weigh each component according to the above content, first add sucrose and citric acid into the high-speed mixing granulator and mix for 1min, the mixing speed is 400rpm, and the cutting speed is 3000rpm, then sodium citrate, strawberry powder essence and Add cefdinir, turn on the granulatin...

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Abstract

The invention provides a cefdinir (C14H13N5O5S2), citric acid and sodium citrate dry suspension composition and a preparation method thereof. The cefdinir, citric acid and sodium citrate dry suspension composition comprises the following components in parts by weight: 100 parts of cefdinir, 1900-2100 parts of a diluent, 120-200 parts of a flocculant, 28-35 parts of a corrigent, 185-195 parts of an adhesive, 15-30 parts of a suspending aid, 8-12 parts of a flow aid and 1.5-2.5 parts of a lubricant. The cefdinir, citric acid and sodium citrate dry suspension composition disclosed by the invention is convenient for being taken by patients, and has high bioavailability and stability.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefdinir (C 14 h 13 N 5 o 5 S 2 ) and citric acid and sodium citrate dry suspension composition. Background technique [0002] Cefdinir is a new generation of cephalosporin 3rd generation oral antibiotics, first synthesized in 1988, began to be used in Japan in 1991, was approved by the US FDA in December 1997, and began to be used in the United States. Because cefdinir is well absorbed orally, with few adverse reactions and broad antibacterial spectrum, it is not only effective against Gram-negative bacteria (G-), but also has high antibacterial activity against Gram-positive bacteria (G+), so it is widely used in clinical application. As for cefdinir drugs, there are "Quanzefu Capsules" produced by Xi'an Janssen and "Shifuni Capsules" produced by Tianjin Central Pharmaceutical Co., Ltd. on the domestic market. [0003] At present, domestically produced cefdin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/546A61K47/26A61K47/12A61P31/04
Inventor 王震郑方晔於长权武莉邓洪丽秦丽君郭洁芬
Owner XIAN ENCI PHARMA CO LTD
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