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Thin-type PCR instrument for heat storage and heat radiation by utilization of overall structure

An integral, heat-dissipating structure technology, applied in specific-purpose bioreactors/fermenters, biochemical instruments, biochemical equipment and methods, etc. Larger, larger temperature difference between two ends of TE sheet, etc., to avoid low heat dissipation efficiency, increase heat storage capacity, and increase conduction speed

Active Publication Date: 2015-04-29
COYOTE BIOSCI YIXING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This also causes a temperature gradient between the end of the radiator close to the TE sheet and the end far away from the TE sheet, which increases the temperature difference between the two ends of the TE sheet, and the required power of the TE sheet also increases.
Obviously, increasing the radiator and fan brings the following disadvantages: large volume, heavy machine, loud noise
Therefore, most of the thermal cyclers on the market are bulky, and there has never been a thin TE sheet-type thermal cycler.

Method used

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  • Thin-type PCR instrument for heat storage and heat radiation by utilization of overall structure
  • Thin-type PCR instrument for heat storage and heat radiation by utilization of overall structure
  • Thin-type PCR instrument for heat storage and heat radiation by utilization of overall structure

Examples

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Embodiment 1

[0020] Such as image 3 In the PCR instrument shown, the upper end of the TE sheet is an aluminum sample holder with a very thin well wall and a very light weight, which can be formed into a 0.2mL PCR test tube with 16 individual wells. The lower end of the TE sheet is a copper block with heat storage effect. The thermal capacity and thermal conductivity of copper are greater than that of aluminum, which is more suitable for the core component of the energy storage device. Below the copper block, there is a relatively large mass of aluminum block as an energy storage, and structurally as the bottom plate and surrounding shell of the overall casing. The thermal conductivity of aluminum blocks is very high in solids, only lower than gold, silver and copper, which can better meet one of the requirements of energy storage; the characteristic heat capacity of aluminum is also better than many other solid materials; the price of aluminum is relatively low, It is easy to process and...

Embodiment 2

[0022] Such as Figure 4 In the PCR instrument shown, the upper end of the TE sheet is an aluminum sample holder with a very thin well wall and a very light weight, which can be formed into a 0.2mL PCR test tube with 16 individual wells. The lower end of the TE sheet is a copper block with heat storage effect. The thermal capacity and thermal conductivity of copper are greater than that of aluminum, which is more suitable for the core component of the energy storage device. Below the copper block, there is a relatively large mass of aluminum block as an energy storage, and structurally as the bottom plate and surrounding shell of the overall casing. The thermal conductivity of aluminum blocks is very high in solids, only lower than gold, silver and copper, which can better meet one of the requirements of energy storage; the characteristic heat capacity of aluminum is also better than many other solid materials; the price of aluminum is relatively low, It is easy to process an...

Embodiment 3

[0024] Such as Figure 5 In the PCR instrument shown, the upper end of the TE sheet is an aluminum sample holder with a very thin well wall and a very light weight, which can be formed into a 0.2mL PCR test tube with 16 individual wells. The lower end of the TE sheet is a copper block with heat storage effect. The thermal capacity and thermal conductivity of copper are greater than that of aluminum, which is more suitable for the core component of the energy storage device. Below the copper block, there is a relatively large mass of aluminum block as an energy storage, and structurally as the bottom plate and surrounding shell of the overall casing. The thickness of copper block and aluminum bottom plate is not less than 6mm to achieve good heat conduction and energy storage effect. The aluminum block accumulator on the bottom plate is a composite structure of aluminum and water. There is a cavity in the aluminum block, and water (or other liquid with large heat capacity) is...

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Abstract

The invention discloses a thin-type PCR instrument, which comprises a casing, an integral-type heat radiation structured temperature-up and temperature-down movement and a sample rack which is positioned on the movement and used for placing sample pipes, wherein the integral-type heat radiation structure comprises a metal soleplate which is far heavier than the sample rack in weight and has a heat storage function. The space of a radiator is saved by installing a radiating fin structure on the upper surface or lower surface of the metal soleplate. The casing and soleplate can be integrated into one piece, are prepared from a material with high thermal capacitivity and high thermal conductivity, and can be used as a part of a heat storage and heat radiation structure. Through an integral-type heat radiation structure of the PCR instrument, adoption of too high and too large radiating fins for heat radiation are avoided such that a traditional semiconductor heating-and-cooling type PCR instrument can be made thinner. By introducing a heat storage module with large thermal capacitance into the PCR instrument, heat absorbing and releasing efficiency of the PCR instrument can be optimized, power of the PCR instrument can also be minimized, and volume and energy consumption of the instrument are further reduced.

Description

technical field [0001] The invention relates to a biomedical experimental instrument, in particular to an instrument for polymerase chain reaction—PCR instrument. Background technique [0002] A PCR instrument is an instrument that heats up and cools down samples through cyclical heating and cooling. At present, the most common PCR instrument is realized by a semiconductor refrigeration chip (TE chip). The following discussion will take cooling as an example. The principle of heating is the same as that of cooling, but the thermal efficiency of cooling is relatively low. Taking refrigeration as an example, the TE sheet acts like a heat pump. After inputting electric energy, the TE sheet can absorb heat from one end (cold end) of the working board, and the other end (hot end) contacts the radiator, and releases a large amount of heat to the environment through the radiator. , to achieve cooling function. The amount of heat absorbed by the heat pump is related to the temper...

Claims

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Application Information

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IPC IPC(8): C12M1/00
Inventor 李响
Owner COYOTE BIOSCI YIXING CO LTD