Production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid

A technology of oxytetracycline base and production process, which is applied in the field of production technology for extracting oxytetracycline base, can solve the problems of rising production cost of oxytetracycline base, rising price of oxalic acid, lowering competitiveness, etc., and reducing the cost of purchasing raw materials , the effect of improving market competitiveness and reducing production costs

Active Publication Date: 2013-08-14
INNER MONGOLIA KAISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the production process of oxytetracycline base, due to the use of a large amount of oxalic acid, the price of oxalic acid continues to rise and remain high, resulting in an increase in the production cost of oxytetracycline base (raw material drug), which makes enterprises compete in the production industry of oxytetracycline base Power decreases year by year

Method used

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  • Production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: a production process for extracting oxytetracycline base by using hydrochloric acid and oxalic acid in combination, comprising the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization and crystallization; (4) drying, powder mixing and packaging The finished product of oxytetracycline base is obtained;

[0022] Wherein, step (1) fermentation comprises:

[0023] a. Preparation of slanted spores: culturing spores: the slanted spores were cultured at 36°C, the humidity was 55%, and the incubation time was 96 hours;

[0024] b. Cultivation in the primary seed tank: the cultivation temperature is 30.5°C, the equipment is sealed, and the air is stirred. After about 26 hours of fermentation, it is moved into the secondary seed tank;

[0025] c. Secondary seed tank cultivation: the cultivation temperature is 30.5°C, mechanical stirring, sterile air is passed, and the fermentation is carried out for 20h and transferred to the tertiary...

Embodiment 2

[0035] Embodiment 2: a production process for extracting oxytetracycline base by using hydrochloric acid and oxalic acid in combination, comprising the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization and crystallization; (4) drying, powder mixing and packaging The finished product of oxytetracycline base is obtained;

[0036] Wherein step (1) fermentation comprises:

[0037] a. Preparation of slanted spores: culturing spores: the slanted spores were cultured at 37°C, the humidity was 60%, and the incubation time was 120h;

[0038] b. First-class seed tank cultivation: the cultivation temperature is 31.5 ℃, the equipment is sealed, and the air is stirred. After about 28 hours of fermentation, it is moved into the second-class seed tank;

[0039] c. Secondary seed tank cultivation: the cultivation temperature is 31.5 °C, mechanical stirring, sterile air is passed, and the fermentation is carried out for 28 hours and then transferred to the te...

Embodiment 3

[0049] Embodiment 3: a production process for extracting oxytetracycline base by using hydrochloric acid and oxalic acid in combination, comprising the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization and crystallization; (4) drying, powder mixing and packaging The finished product of oxytetracycline base is obtained;

[0050] Wherein, step (1) fermentation comprises:

[0051]a. Preparation of slanted spores: culturing spores: the slanted spores were cultured at 36.5°C, the humidity was 58%, and the incubation time was 110h;

[0052] b. Cultivation in the primary seed tank: the cultivation temperature is 31°C, the equipment is sealed, the air is stirred, and after about 27 hours of fermentation, it is moved into the secondary seed tank;

[0053] c. Secondary seed tank cultivation: the cultivation temperature is 31 °C, mechanical stirring, sterile air is passed, and the fermentation is carried out for 24h and transferred to the tertiary ferme...

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Abstract

The invention discloses a production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid. The production technology comprises the following steps of: (1) fermenting; (2) acidizing and filtering; (3) decoloring and crystallizing; (4) drying, mixing and packaging to prepare an oxytetracycline dihyclorate product, wherein the step (2) is as follows: acidizing a fermentation liquor, namely adding oxalate to the fermentation liquor prepared in the step (1) to adjust the PH value of the fermentation liquor to 2.10-2.20; and then adding hydrochloric acid to the fermentation liquor, and adjusting the PH value of the fermentation liquor to 1.80-2.0. The production technology has the advantages that adjustment is carried out by an extraction and acidification process; the production cost of a company is greatly reduced by the hydrochloric acid and the oxalate; the purchasing cost of raw materials is reduced; the production cost can be saved by **-** each month; the production cost is reduced; and the market competitiveness of an enterprise is improved.

Description

technical field [0001] The invention relates to a production process for extracting oxytetracycline alkali, in particular to a production process for extracting oxytetracycline alkali by combining hydrochloric acid and oxalic acid. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic, prepared by soil Streptomyces, against Gram-positive and negative bacteria, erythropoiesis, chlamydia, mycoplasma, rickettsia, spirochetes, actinomycetes, vibrio and Certain protozoa (eg: coccidia) have inhibitory effects. Nowadays, it is mainly used in livestock and poultry medicines and feed additives. [0003] In the production process of oxytetracycline alkali, due to the use of a large amount of oxalic acid, the price of oxalic acid continues to rise and remains high, resulting in the increase of the production cost of oxytetracycline alkali (raw drug), which makes enterprises compete in the oxytetracycline alkali production industry. The power decreases year by y...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P15/00C07C237/26C07C231/24
Inventor 李建昭
Owner INNER MONGOLIA KAISHENG BIOTECH
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