Method for preparing water-soluble ferroferric oxide nano particle

A technology of ferric tetroxide and nanoparticles, which is applied in the directions of iron oxide/iron hydroxide, nanotechnology, nanotechnology, etc., can solve the problems of poor water solubility and limited application, and achieves low cost, simple method and good superparamagnetic properties. energy effect

Inactive Publication Date: 2013-09-04
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The iron ferric oxide nanoparticles prepared by this method have the characteristics of good crystal form, good dispersion and uniform particle size distribution, but their water solubility is poor, which limits its application in biomedicine and other fields.

Method used

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  • Method for preparing water-soluble ferroferric oxide nano particle
  • Method for preparing water-soluble ferroferric oxide nano particle
  • Method for preparing water-soluble ferroferric oxide nano particle

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The preparation method of water-dispersible ferric oxide nanoparticles, the steps are as follows:

[0037] 1) Dissolve 0.648g (4mmol) of anhydrous ferric chloride and 0.48g (1.6mmol) of trisodium citrate in 40mL of diethylene glycol, heat to 70-80°C, and stir until it is completely dissolved;

[0038] 2) Add 1.0 g (12 mmol) of anhydrous sodium acetate to the mixed solution obtained in step 1), and wait until it is completely dissolved;

[0039] 3) The homogeneous mixed solution obtained in step 2) is placed in a stainless steel reaction kettle of polytetrafluoroethylene, the reaction kettle is closed, and the reaction is carried out at a constant temperature of 200 ° C for 6 hours. After the reaction is completed, it is naturally cooled to room temperature;

[0040] 4) The ferric oxide nanoparticles were separated from the reaction solution with a magnet, and the obtained product was washed three times with absolute ethanol and deionized water at room temperature, and t...

Embodiment 2

[0045] The preparation method of water-dispersible ferric oxide nanoparticles, the steps are the same as those in Example 1, the difference is that the reaction is carried out at a constant temperature of 200° C. for 4 hours. see figure 2 Transmission electron microscopy (TEM) topography pictures shown and Figure 5 X-ray diffraction (XRD) pattern shown in curve a.

Embodiment 3

[0047] The preparation method of water-dispersible ferric oxide nanoparticles, the steps are the same as those in Example 1, the difference is that the reaction is carried out at a constant temperature of 200° C. for 10 hours. see image 3 Transmission electron microscopy (TEM) topography pictures shown and Figure 5 X-ray diffraction (XRD) pattern shown in curve c.

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Abstract

The invention discloses a method for preparing a water-soluble ferroferric oxide nano particle, relates to a nano particle, and provides the ferroferric oxide nano particle which has the grain diameter of less than 4 nm and narrow particle diameter distribution. The method for preparing the water-soluble ferroferric oxide nano particle of a typical monodisperse particle is provided. The method comprises the steps as follows: 1), anhydrous ferric chloride and trisodium citrate are immersed in diethylene glycol and heated until the anhydrous ferric chloride and the trisodium citrate are dissolved completely; 2), anhydrous sodium acetate is added into a mixed solution obtained in the step 1), and the mixed solution is waited to be dissolved completely; 3), the mixed solution obtained in the step 2) is placed into a reaction still, the reaction still is closed, and after the reaction, the mixed solution is naturally cooled to the room temperature; and 4), the ferroferric oxide nano particle is separated from the reaction solution prepared in the step 3) by a magnet, the particle is washed and dried, so that the monodisperse water-soluble ferroferric oxide nano particle is obtained.

Description

technical field [0001] The invention relates to a nanoparticle, in particular to a preparation method of a water-soluble ferric oxide nanoparticle. Background technique [0002] Ferrous oxide nanoparticles have unique magnetic properties and good biocompatibility, and are widely used in magnetic fluids, special catalyst raw materials, magnetic dyes, data storage and biomedicine. Especially in the field of biomedicine, ferric oxide nanoparticles have great application prospects in drug targeted delivery, tumor hyperthermia therapy, MRI, tissue repair and immune detection. [0003] At present, the preparation methods of Fe3O4 nanoparticles mainly include physical methods and chemical methods. Nanoparticles prepared by physical methods have the characteristics of low purity and non-uniform particle distribution. Among the chemical methods, the co-precipitation method is to hydrolyze the iron salt under alkaline conditions. This method can obtain water-soluble ferric oxide nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08B82Y30/00
Inventor 任磊沈礼华
Owner XIAMEN UNIV
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