Method for preparing polymer fluorescent microsphere

A fluorescent microsphere and polymer technology, applied in the field of polymer fluorescent microsphere preparation, can solve the problems of difficult to obtain microspheres with highly uniform particle size and difficult to control the particle size of fluorescent microspheres, and achieve stable microsphere structure and use of raw materials The effect of small amount and high uniformity of particle size

Inactive Publication Date: 2013-09-04
NANJING UNIV OF TECH
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Problems solved by technology

In addition, the existing methods are difficult to control the particle size of fluorescent microspheres during the preparation process, and at the same time it is difficult to obtain microspheres with highly uniform particle size

Method used

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  • Method for preparing polymer fluorescent microsphere
  • Method for preparing polymer fluorescent microsphere
  • Method for preparing polymer fluorescent microsphere

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Embodiment Construction

[0028] The present invention will be further described in detail below with reference to the accompanying drawings and examples. However, the invention is not limited to the examples given.

[0029] This embodiment uses a T-tube microfluidic device: insert one end of a polytetrafluoroethylene capillary tube with a length of 5 cm and an inner diameter of 1 mm into one end of a polydimethylsiloxane pipe with an inner diameter of 2 mm and a length of 10 cm to form a T-shaped channel . The other end of the polytetrafluoroethylene capillary was used as the inlet of the continuous phase, one end of the polydimethylsiloxane tube was inserted into a 27G needle as the inlet of the discontinuous phase, and the other end was used as the outlet of the polymer fluorescent microspheres. Use a watch glass filled with the continuous phase solution as a receiving device for fluorescent microspheres, and place it below the outlet end of the polydimethylsiloxane pipeline (such as figure 1 show...

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Abstract

The invention relates to a method for preparing a polymer fluorescent microsphere. The method comprises the following steps of: 1, preparing polymer fluorescent microsphere liquid drops, namely dissolving a first polymer into a solvent, adding a fluorescent material into the solvent, magnetically and uniformly stirring the fluorescent material and the first polymer in the solvent to prepare a non-continuous phase, respectively putting the non-continuous phase and a continuous phase into injectors connected with a non-continuous phase inlet and a continuous phase inlet of a microfluid device, adjusting the flowing speeds of the two phases of solutions through a trace sample injection pump, so as to obtain the fluorescent microsphere liquid drops, and at a microfluid outlet, collecting the fluorescent microsphere liquid drops into a fluorescent microsphere receiving device; and 2, preparing the polymer fluorescent microsphere, namely drying the fluorescent microsphere liquid drops until the solvent is completely volatilized, then washing the fluorescent microsphere liquid drops by a washer, and cleaning the continuous phase of solution to finally obtain the polymer fluorescent microsphere. Equipment used by the method is simple and convenient to operate; the particle size of the microsphere can be adjusted by adjusting the flowing speeds of the continuous phase and the non-continuous phase; and the uniformity of the particle sizes of the prepared microspheres is high.

Description

technical field [0001] The invention relates to a method for preparing polymer fluorescent microspheres, more specifically to a method for preparing polymer fluorescent microspheres based on microfluidic technology. Background technique [0002] Fluorescent microspheres refer to particles loaded with fluorescent substances on the surface or inside, which can emit fluorescence under the stimulation of external conditions, and their shape is generally spherical. Fluorescent microspheres, as a special kind of functional microspheres, are widely used in biology, medicine, chemistry, electronics and other fields due to their stable morphology, narrow particle size distribution, good monodispersity and high fluorescence luminous efficiency. According to different carriers and fluorescent substances, fluorescent microspheres are usually divided into three categories: inorganic / organic fluorescent microspheres, inorganic / inorganic fluorescent microspheres, and organic / organic fluore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C09K11/65C09K11/88C09K11/56B01J13/02
Inventor 陈苏朱亮亮王彩凤
Owner NANJING UNIV OF TECH
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