Preparation method of six-ingredient capsule
The technology of Liurui capsules and encapsulation is applied in the field of preparation of Liurui capsules, which can solve the problems of insufficient utilization of valuable medicinal materials, large loss of effective components, low drug bioavailability, etc., and achieves safe and reliable drug efficacy and product quality. Stable, reasonable effect of drug use
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[0016] A preparation method of Liurui capsule, specifically comprising the following steps:
[0017] Step 1, weighing 22% to 28% pitted Myrobalan, 22% to 28% safflower, 22% to 28% pascha, 10% to 16% woody, 10% to 16% Benzoin, 0.3%~0.9% artificial musk, the weight percentage sum of the above components is 100%;
[0018] Step 2, pre-freeze the cored myrobalan, safflower, paschaga, woody fragrance, and benzoin at a temperature of -30 to -35°C for 60 to 70 minutes, freeze and pulverize them at a low temperature for 20 to 25 minutes, and make them into 700 to 800 Target nanopowder, spare;
[0019] Step 3, using copovidone Plasdone-630 as a carrier for the artificial musk fine powder, the ratio of raw and auxiliary materials is 7-9:3-1, using hot-melt extrusion technology, the temperature is 30-40°C, and the screw speed is 500-600 rpm Minutes, the material is extruded in strips from the die hole of the machine head, and the extruded product is connected to an aluminum plate, place...
Embodiment 1
[0043] Step 1, take respectively by weight percentage the myrobalan of 22% pitting, 23.5% safflower, 28% paschaga, 10% woody fragrance, 16% benzoin, 0.5% artificial musk, the weight percentage sum of above each component is 100%;
[0044] Step 2, pre-freeze the denuclear myrobalan, safflower, paschaga, woody fragrance and benzoin at -30°C for 60 minutes, freeze and pulverize them at low temperature for 25 minutes, and make them into 700-mesh nano-powder for later use;
[0045] Step 3: Use copovidone Plasdone-630 as the carrier for artificial musk fine powder, the ratio of raw and auxiliary materials is 7:3, adopt hot-melt extrusion technology, the temperature is 35°C, the screw speed is 550 rpm, and the material is passed through the die hole of the machine head Extrude in strips, connect the extruded product to an aluminum pan, place it at room temperature for 3 hours, crush it, and pass it through a 100-mesh sieve for later use;
[0046] Step 4, mix the nano-powder obtained...
Embodiment 2
[0048] Step 1, take respectively by weight percentage the myrobalan of 25% pitting, 22% safflower, 25% paschaga, 16% woody fragrance, 11.6% benzoin, 0.4% artificial musk, the weight percentage sum of above each component is 100%;
[0049] Step 2, pre-freezing the denuclear myrobalan, safflower, paschaga, woody fragrance, and benzoin at -35°C for 65 minutes, freezing and pulverizing them at low temperature for 20 minutes, and making them into 800-mesh nano-powders for later use;
[0050] Step 3: Use copovidone Plasdone-630 as the carrier for the artificial musk fine powder, the ratio of raw and auxiliary materials is 9:1, adopt hot-melt extrusion technology, the temperature is 30°C, the screw speed is 600 rpm, and the material is passed through the die hole of the machine head Extrude in strips, connect the extruded product to an aluminum tray, place it at room temperature for 4 hours, crush it, and pass it through a 200-mesh sieve for later use;
[0051] Step 4, mix the nano-...
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