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Danshan fat reducing granules and preparation method thereof

A technology of Danshan Xiaozhi Granules, which is applied in the field of Danshan Xiaozhi Granules and its preparation, to achieve the effects of convenient storage, good therapeutic effect and stable properties

Inactive Publication Date: 2013-09-25
湖北省中医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In fact, there is no direct evidence that blood lipid-lowering drugs can reduce the fat deposition in the liver itself.
And most lipid-lowering drugs are hepatotoxic, so blood-lipid-lowering drugs should be used with caution in the treatment of NAFLD

Method used

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  • Danshan fat reducing granules and preparation method thereof
  • Danshan fat reducing granules and preparation method thereof
  • Danshan fat reducing granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Extraction Technology of Danshan Xiaozhi Granules

[0040] 1. The water extraction process of Danshan Xiaozhi Granules, the steps are as follows:

[0041] (1) Proportionally weigh 2 times the prescription amount of medicinal materials, add a certain amount of water according to the orthogonal test factor level table, and soak thoroughly. See Table 1 for the factor level table.

[0042] (2) After soaking, decoct according to the test number corresponding to the orthogonal test table, and filter to obtain the filtrate.

[0043] (3) Determine the contents of tanshinone IIA, salvianolic acid B and chrysophanol in the filtrate respectively, and measure the yield of dry paste.

[0044] (4) Taking dry paste rate, tanshinone IIA, salvianolic acid B, and chrysophanol content as evaluation indexes, the optimal decoction process was determined by analytic hierarchy process. The experimental design and results are shown in Table 2.

[0045] Table 1 Factor level table of orthogo...

Embodiment 2

[0064] Screening of Pharmaceutical Excipients for Danshan Xiaozhi Granules

[0065] The screening steps for pharmaceutical excipients are as follows:

[0066] (1) Decoct in water according to the optimal decoction process, filter with a 400-mesh filter cloth, and obtain the filtrate.

[0067] (2) Concentrate the filtrate under reduced pressure at a concentration temperature of 60°C, and dry under reduced pressure to obtain a dry cream powder.

[0068] (3) Investigate the moisture absorption rate of dry ointment powder and different pharmaceutical excipients mixed in 1:1, the results are shown in Table 6 and figure 2 .

[0069] Table 6 Hygroscopicity test results of different excipients

[0070]

[0071] Note: Percentage of moisture absorption (%) = (weight of powder after moisture absorption - weight of powder before moisture absorption) / weight of powder before moisture absorption X100%

[0072] Conclusion: All of the above excipients can improve the hygroscopicity o...

Embodiment 3

[0074] Screening of the amount of excipients in Danshan Xiaozhi Granules

[0075] The preparation process of Danshan Xiaozhi Granules is as follows:

[0076] (1) Decoct in water according to the optimal decoction process, filter with a 400-mesh filter cloth, and obtain the filtrate;

[0077] (2) The filtrate was concentrated under reduced pressure at a concentration temperature of 60°C, and dried under reduced pressure to obtain a dry cream powder;

[0078] (3) Mix the obtained dry paste powder with dextrin in different proportions, granulate with ethanol with a volume concentration of 60% as a binder, dry at 60°C, and granulate to obtain Danshan Xiaozhi Granules. The results are shown in Table 7.

[0079] Table 7 Results of dextrin dosage investigation

[0080]

[0081] The results showed that it is reasonable to mix Danshan Xiaozhi Granules dry paste powder and dextrin at a ratio of 1:1 for granulation considering the difficulty of granulation, the properties and yield ...

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Abstract

The invention relates to Danshan fat reducing granules and a preparation method thereof. The Danshan fat reducing granules is prepared by three kinds of traditional Chinese medicines of red sage root, fried cassia seed and haw in a mass proportion of 4:3:2. The preparation method comprises the following steps of: (1) weighting Danshan fat reducing granule medicinal material decoction pieces of twice of a prescription amount, adding water with weight ten times of that of the medicinal materials, boiling and extracting three times and 1h per time; (2) after the step (1), filtrating with 100-300-mesh filter cloth, to obtain filtrate; (3) condensing the filtrate by pressure reduction at 50-70 DEG C, and drying by pressure reduction to obtain dried paste powder; (4) mixing the obtained dried paste powder and medicinal dextrin in a mass proportion of 1:1, pelletizing by using ethanol as an adhesive, drying at 50-70 DEG C, straightening granules, and packaging, to obtain the Danshan fat reducing granules. Yield of the Danshan fat reducing granules by the method can reach 96%, and the method can be used for industrialization production. The Danshan fat reducing granules can be used as a medicine for treating a non-alcoholic fatty liver disease.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparation technology, in particular to Danshan Xiaozhi Granules and a preparation method thereof. Background technique [0002] The liver is an important organ that plays a role in metabolism in the human body. It plays an important role in the absorption, digestion, transformation, synthesis, and decomposition of lipids, and can maintain the dynamic balance of fat in the body. At present, it is believed that under normal circumstances, the content of fat in the liver accounts for 5% of the liver weight, of which more than 60% is phospholipids, and triglycerides account for 1%, and cholesterol accounts for about 0.5%. main component of cell membrane [1] . In histology, when the degree of fatty liver parenchyma reaches more than 30%, or when the accumulation of fat in liver cells reaches more than 5% of the wet weight of the liver, it can be called fatty liver. With the in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K9/16A61P1/16
Inventor 盛国光李晓东陈树和徐建良黄育华
Owner 湖北省中医院
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