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Method for preparing monodispersed alpha-Fe2O3 nanoparticles

A nanoparticle, monodisperse technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., to achieve the effect of excellent biocompatibility

Inactive Publication Date: 2013-10-02
HUNAN PROVINCIAL TUMOR HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, Fe 2 o 3 The cellular response and cytotoxicity induced by nanoparticles remain largely debated

Method used

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  • Method for preparing monodispersed alpha-Fe2O3 nanoparticles
  • Method for preparing monodispersed alpha-Fe2O3 nanoparticles
  • Method for preparing monodispersed alpha-Fe2O3 nanoparticles

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Prepare 10mL0.4mol / L ferric nitrate solution: weigh 1.47g Fe(NO 3 ) 3 ·7H 2 O, dissolved in 10mL ultrapure water, shake at low speed (100rpm) to dissolve completely.

[0032] (2) Prepare 10 mL of 0.4 mol / L glycine solution: weigh 0.30 g of glycine, dissolve it in 10 mL of ultrapure water, and dissolve it completely under ultrasonic conditions.

[0033] (3) Transfer the solutions in (1) and (2) to a hydrothermal reaction kettle with a volume of 150 mL, and add 47 mL of ultrapure water and 33 mL of absolute ethanol. After buckling the lid of the reaction kettle, shake for 1 min to mix the solution evenly.

[0034] (4) The reaction kettle was placed in a temperature-programmed device, with a heating rate of 20 degrees per minute, and after the temperature was finally stabilized at 180 degrees, the reaction time was controlled to be 12 hours.

[0035] (5) Cool to room temperature after the reaction is complete, wash the obtained product three times with ethanol and ...

Embodiment 2

[0037] (1) Prepare 8mL0.2mol / L ferric nitrate solution: weigh 0.735g Fe(NO 3 ) 3 ·7H 2 O, dissolved in 8mL ultrapure water, shake at low speed (80rpm) to dissolve completely.

[0038] (2) Prepare 10 mL of 0.2 mol / L glycine solution: weigh 0.15 g of glycine, dissolve it in 10 mL of ultrapure water, and dissolve it completely under ultrasonic conditions.

[0039] (3) Transfer the solutions in (1) and (2) to a hydrothermal reaction kettle with a volume of 150 mL, and add 24 mL of ultrapure water and 16 mL of absolute ethanol. After buckling the lid of the reaction kettle, shake for 2 minutes to mix the solution evenly.

[0040] (4) The reaction kettle was placed in a temperature-programmed device, with a heating rate of 15 degrees per minute, and after the temperature was finally stabilized at 175 degrees, the reaction time was controlled to be 10 hours.

[0041] (5) Cool to room temperature after the reaction is complete, wash the obtained product three times with ethanol an...

Embodiment 3

[0043] (1) Prepare 12mL0.6mol / L ferric nitrate solution: weigh 2.646g Fe(NO 3 ) 3 ·7H 2 O, dissolved in 12mL ultrapure water, shake at low speed (120rpm) to dissolve completely.

[0044] (2) Prepare 10 mL of 0.6 mol / L glycine solution: weigh 0.45 g of glycine, dissolve it in 10 mL of ultrapure water, and dissolve it completely under ultrasonic conditions.

[0045] (3) Transfer the solutions in (1) and (2) to a hydrothermal reaction kettle with a volume of 150 mL, and add 72 mL of ultrapure water and 60 mL of absolute ethanol. After buckling the lid of the reaction kettle, shake for 3 minutes to mix the solution evenly.

[0046] (4) The reaction kettle was placed in a temperature-programmed device, and the temperature was finally stabilized at 185 degrees at a heating rate of 25 degrees per minute, and the reaction time was controlled to be 14 hours.

[0047] (5) After the reaction is complete, cool to room temperature, wash the obtained product three times with ethanol and...

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Abstract

The invention discloses a method for preparing monodispersed alpha-Fe2O3 nanoparticles. The method comprises the following steps of firstly preparing a ferric nitrate solution and a glycine solution; then adding the above solutions into a hydrothermal reactor; then adding ultrapure water and absolute ethyl alcohol into the hydrothermal reactor; mixing the above materials uniformly; putting the reactor in a temperature-programmed controller; carrying out programmed temperature to make the temperature stabilized at 175-185 DEG C; reacting for 10-14 h at the temperature; cooling the reactor to a room temperature after the reaction is finished; washing the obtained reaction product with absolute ethyl alcohol and ultrapure water; and finally drying the reaction product with an oven. The method disclosed by the invention is simple and economic and has good repeatability; the prepared alpha-Fe2O3 nanoparticles have a hexagonal system structure, an average particle size of 50 nm and very large cell absorption efficiency and high biocompatibility and have particularly large application prospects in aspects such as conveying drugs or targeted therapy, etc.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a method for preparing monodisperse α-Fe 2 o 3 nanoparticle approach. Background technique [0002] In recent years, nanoparticles have unique physical and chemical properties due to quantum confinement effects and quantum size effects, attracting extensive attention from researchers in the fields of biology and biomedicine. Among them, iron oxide nanoparticles have become the most commonly used nanomaterials in the most commonly used biological and life science researches due to their unique advantages such as high thermodynamic stability, magnetic properties and catalytic properties. Their applications include the detection of biomolecules, Magnetic resonance imaging, biocatalysis, gene or drug-targeted transfection, and more. In order to obtain functionalized nanomaterials suitable for biological applications, iron oxide nanoparticles first need to have good biocompat...

Claims

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Application Information

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IPC IPC(8): C01G49/06B82Y30/00
Inventor 周辉陈建华肖玲罗永忠
Owner HUNAN PROVINCIAL TUMOR HOSPITAL
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