A kind of preparation method of d-tryptophan
A tryptophan and white technology, applied in the field of D-tryptophan, can solve the problems of poor quality of D-tryptophan and high purity of D-tryptophan, and achieve low environmental pollution, high purity, simple and efficient process Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0046] A kind of D-tryptophan of the present embodiment, its synthetic steps are:
[0047] Step A, first put L-tryptophan and solvent into the reaction kettle, then put in the racemic agent, raise the temperature to 40°C, stir for 0.5h, then add the resolving agent, and raise the temperature to 2°C / min at the same time 95°C, keep warm for 24 hours, wherein: the mass ratio of L-tryptophan to solvent is 1:4.8, the mass ratio of L-tryptophan to racemic agent is 1:0.39, the mass ratio of L-tryptophan to resolving agent The mass ratio is 1:0.9, the solvent in this example is water, the resolving agent is 2,3-dihydroxysuccinic acid, and the racemic agent is sodium hydroxide;
[0048] After step B, step A, carry out following temperature control process to the mixture that step A makes:
[0049] 1) Cool down to 90°C, keep warm for 24 hours,
[0050] 2) Cool down to 85°C, keep warm for 12h,
[0051] 3) Cool down to 80°C, keep warm for 10h,
[0052] 4) Cool down to 75°C, keep warm ...
Embodiment 2
[0073] A kind of D-tryptophan of the present embodiment, its synthetic steps are:
[0074] Step A, first put L-tryptophan and solvent into the reaction kettle, then put in the racemic agent, raise the temperature to 40°C, stir for 0.5h, then add the resolving agent, and raise the temperature to 2°C / min at the same time 95°C, keep warm for 24 hours, wherein: the mass ratio of L-tryptophan to solvent is 1:4.5, the mass ratio of L-tryptophan to racemic agent is 1:0.4, the mass ratio of L-tryptophan to resolving agent The mass ratio is 1:0.8, the solvent in this embodiment is water, the resolving agent is α-methylbenzylamine, and the racemic agent is salicylaldehyde;
[0075] After step B, step A, carry out following temperature control process to the mixture that step A makes:
[0076] 1) Cool down to 90°C, keep warm for 24 hours,
[0077] 2) Cool down to 85°C, keep warm for 12h,
[0078] 3) Cool down to 80°C, keep warm for 10h,
[0079] 4) Cool down to 75°C, keep warm for 15...
Embodiment 3
[0093] A kind of D-tryptophan of the present embodiment, its synthetic steps are:
[0094] Step A, first put L-tryptophan and solvent into the reaction kettle, then put in the racemic agent, raise the temperature to 40°C, stir for 0.5h, then add the resolving agent, and raise the temperature to 2°C / min at the same time 95°C, keep warm for 24 hours, wherein: the mass ratio of L-tryptophan to solvent is 1:5, the mass ratio of L-tryptophan to racemic agent is 1:0.38, the mass ratio of L-tryptophan to resolving agent The mass ratio is 1:1, the solvent in the present embodiment is water, the resolving agent is dextroamino, and the racemic agent is acetic acid;
[0095] After step B, step A, carry out following temperature control process to the mixture that step A makes:
[0096] 1) Cool down to 90°C, keep warm for 24 hours,
[0097] 2) Cool down to 85°C, keep warm for 12h,
[0098] 3) Cool down to 80°C, keep warm for 10h,
[0099] 4) Cool down to 75°C, keep warm for 15h,
[0...
PUM
| Property | Measurement | Unit |
|---|---|---|
| density | aaaaa | aaaaa |
| melting point | aaaaa | aaaaa |
| flash point | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More