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Particles for livestock liver and gall and preparation method thereof

A technology for granule preparations and hepatobiliary diseases, which is applied in the field of granule preparations for the treatment of animal hepatobiliary diseases and its preparation, can solve the problems of unclear process parameters, loss of effective substances, shortening the course of treatment, etc., and achieve simple process control, reduce losses, and avoid mutual effect of influence

Active Publication Date: 2014-08-06
江西仲襄本草生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine extraction process has rough process, unclear process parameters, and serious loss of effective substances. Only by exploring scientific and reasonable extraction agents, extraction processes, and quantifying process parameters can we ensure the efficient extraction of effective substances in Chinese medicinal materials and improve the medicinal value of products. Efficacy, shorten the course of treatment, reduce side effects

Method used

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  • Particles for livestock liver and gall and preparation method thereof
  • Particles for livestock liver and gall and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The formula for the granule preparation for the treatment of animal hepatobiliary disease is calculated in parts by weight,

[0021] Main ingredients: 150 parts of Radix isatidis, 150 parts of Yin Chen;

[0022] Excipients: 24 parts of bifidosaccharides, 12 parts of β-cyclodextrin, and 3 parts of polyvinylpyrrolidone. Bidisose was purchased from Beijing Qinshi Black Food Development Company;

[0023] The specific preparation method of the granule preparation for the treatment of animal liver and gallbladder disease is:

[0024] Primary extraction of effective components of Radix isatidis: Take Radix Radix and crush it to 100 mesh, add 1.2 times the volume of Radix Radix with a mass fraction of 30% ethanol, stir evenly, moisten for 2 hours, open the material valve for percolation, and use 30% mass fraction as the percolation solvent Ethanol, the percolation speed is 7ml / min, and the Radix Radix percolation liquid is collected for later use; Radix Radix Radix Radix Dregs...

Embodiment 2

[0028] The formula for the granule preparation for the treatment of animal hepatobiliary disease is calculated in parts by weight,

[0029] Main ingredients: 100 parts of Banlangen, 100 parts of Yin Chen;

[0030] Excipients: 15 parts of bifidosaccharide, 10 parts of β-cyclodextrin, 2 parts of polyvinylpyrrolidone, and bifidosaccharide was purchased from Beijing Qinshi Black Food Development Company;

[0031] The specific preparation method of the granule preparation for the treatment of animal liver and gallbladder disease is:

[0032] Primary extraction of effective components of Radix isatidis: Take Radix Radix and crush it to 100 mesh, add ethanol with a mass fraction of 1 times the volume of Radix Radix isatidis and 20% mass fraction, stir evenly, moisten for 1 hour, open the material valve for percolation, and select the solvent with a mass fraction of 20% of Radix isatidis Ethanol, the percolation speed is 4ml / min, and the isatidis percolation liquid is collected for s...

Embodiment 3

[0036] The formula for the granule preparation for the treatment of animal hepatobiliary disease is calculated in parts by weight,

[0037] Main ingredients: 200 parts of Banlangen, 200 parts of Yin Chen;

[0038] Excipients: 35 parts of bifidosaccharides, 20 parts of β-cyclodextrin, 4 parts of polyvinylpyrrolidone, and bifidosaccharides were purchased from Beijing Qinshi Black Food Development Company;

[0039] The specific preparation method of the granule preparation for the treatment of animal liver and gallbladder disease is:

[0040] Primary extraction of effective components of Radix isatidis: Take Radix Radix and crush it to 100 mesh, add 1.5 times the volume of Radix Radix with a mass fraction of 40% ethanol, stir evenly, moisten for 3 hours, open the material valve for percolation, and use a mass fraction of 40% as the percolation solvent Ethanol, the percolation speed is 10ml / min, and the Radix Radix percolation liquid is collected for subsequent use; Radix Radix R...

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Abstract

The invention discloses a granule preparation for treating animal liver and gallbladder disease and a preparation method thereof. It is mainly composed of 100-200 parts of Radix isatidis and 100-200 parts of capillary. The two raw materials are firstly extracted from active ingredients, then concentrated by nanofiltration, mixed with auxiliary materials, and spray-dried by a granulator to obtain a finished product. The granule preparation prepared by the invention for treating hepatobiliary diseases of animals has simple process control, high bioavailability, good drug effect, fast curative effect and low cost.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a granule preparation for treating animal liver and gallbladder disease and a preparation method thereof. Background technique [0002] In veterinary clinics, liver and gallbladder disease is a common disease. According to the syndrome differentiation method of TCM veterinary medicine, the symptoms are mainly manifested as inflammation of the liver (manifested as conjunctivitis, keratitis and other diseases), hot liver wind (manifested as high fever, etc.) convulsions, encephalitis and other diseases), stagnation of liver qi (manifested in chronic hepatitis, indigestion, etc.), liver and gallbladder damp heat (manifested in acute jaundice hepatitis, endometritis, orchitis, dry feces and urine Or diarrhea and not well, etc.), liver blood deficiency (manifested in night blindness, dizziness, fundus disease) and other diseases; according to the etiology, course of disease and symp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K36/315A61K9/16A61P1/16A61P31/04
Inventor 付仲襄付宁晨付宁静杨彦平
Owner 江西仲襄本草生物有限公司