Tamoxifen citrate enteric-coated tablets

A technology of tamoxifen and citric acid, applied in the field of enteric-coated tablets, can solve problems such as low bioavailability

Active Publication Date: 2013-10-16
NANTONG GUANGTAI BIOCHEM PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the shortcoming of low bioavailability of existing tamoxifen citrate prepar

Method used

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  • Tamoxifen citrate enteric-coated tablets
  • Tamoxifen citrate enteric-coated tablets
  • Tamoxifen citrate enteric-coated tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Prescription

[0037] Tamoxifen citrate inclusion complex: Tamoxifen citrate: α-cyclodextrin ratio 1:2

[0038] Tamoxifen citrate inclusion compound 25 parts

[0039] The composition of mannitol and microcrystalline cellulose (the weight ratio of the two is 7:2) 22 parts

[0040] 13 parts of 3% polyvinylpyrrolidone 95% ethanol solution

[0041] 8 parts methylcellulose

[0042] Composition of crospovidone and sodium carboxymethyl starch (the weight ratio of the two is 3:4) 7 parts

[0043] Talc powder 2 parts

[0044] Composition of hypromellose phthalate and cellulose acetate phthalate

[0045] (The weight ratio of the two is 1.2:1.8) 5 parts

[0046] Preparation:

[0047] 1. Prepare tamoxifen citrate inclusion compound according to the following method:

[0048] (1) In water or aqueous ethanol medium, react tamoxifen citrate with α-cyclodextrin in a certain proportion, filter the resulting solution through a microporous membrane until clarified, and s...

Embodiment 2

[0053] Fully grind tamoxifen citrate and α-cyclodextrin described in Example 1 in 50% ethanol to form a uniform paste, and obtain a white powder after vacuum drying. Tamoxifen citrate increased 12-fold.

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Abstract

The invention relates to tamoxifen citrate enteric-coated tablets, the preparation method of which comprises the steps of preparing tamoxifen citrates into clathrate compounds and further preparing the clathrate compounds into enteric-coated tablets.

Description

technical field [0001] The present application relates to an enteric-coated tablet, specifically, a tamoxifen citrate inclusion compound enteric-coated tablet. Background technique [0002] Tamoxifen (TAM) is a non-steroidal compound approved by the US Food and Drug Administration in 1977 for the treatment of metastatic breast cancer in postmenopausal women. After nearly 30 years of application history, it is now also used to prevent the occurrence of breast cancer. TAM belongs to the first generation of selective estrogen receptor modulators (selective estrogen receptor modulators, SERMs), which have dual effects of estrogen agonism and estrogen antagonism, and this effect depends on different germlines, tissues and gene expression types, Different target organs or target cells have different effects. For example, TAM produces antagonizing estrogen in mammary gland tissue, while it produces estrogen agonizing effect in uterus and bone tissue. TAM competes with estrogen ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/48A61K47/38A61K47/36A61K47/32A61K47/26A61K47/04A61K31/138A61P35/00
Inventor 李申李春涛邱俊
Owner NANTONG GUANGTAI BIOCHEM PROD
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