Supercharge Your Innovation With Domain-Expert AI Agents!

Method for synthesizing hydroxypropyl methyl cellulose

A technology of hydroxypropyl methylcellulose and a synthesis method, which is applied to the synthesis field of cellulose mixed ethers in the chemical field, can solve the problems of low degree of automation of reaction control, inflexible replacement of varieties, large process equipment and the like, and achieves reaction parameters. Easy to control, easy to realize reaction conditions, good product quality

Active Publication Date: 2013-10-30
美信佳中维药业股份有限公司
View PDF3 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the production of high-viscosity hydroxypropyl methylcellulose mostly adopts a large-scale semi-continuous (Luzhou North) process route. The disadvantages are: large process equipment, inflexible variety replacement, high reaction temperature, and short reaction time. Long, and the degree of automation of reaction control is low, so the accuracy of control is relatively low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 100g of refined cotton is crushed into 0.2-0.4mm fine material with a pulverizer. After evacuating the reactor and using a nitrogen generating device to press nitrogen to replace the air, mix the sodium hydroxide solution (containing 80g of sodium hydroxide) with 1180g of binary organic solvent (made of toluene and isophthalic acid with a mass ratio of 5:1 Propanol) is added into the reactor first, and then the pulverized refined cotton fines are put into the reactor for alkalization treatment to obtain alkali cellulose.

[0032] Put 500g of toluene in the etherifier in advance, pump the alkali cellulose into the etherifier, and add 100g of isopropanol. Add 150 g of methyl chloride and 25 g of propylene oxide to the etherifier in turn, and perform etherification reaction at 40° C. for 50 minutes, and then etherification reaction at 70° C. for 50 minutes to obtain a crude HPMC product.

[0033] Add glyoxal to the crude product of HPMC as a cross-linking agent to make th...

Embodiment 2

[0043] 100g of refined cotton is crushed into 0.2-0.4mm fine material with a pulverizer. After evacuating the reactor and using a nitrogen generating device to press nitrogen to replace the air, the sodium hydroxide solution (containing 85g of sodium hydroxide) and 1200g of binary organic solvent (made of toluene and isophthalic acid with a mass ratio of 10:1 Propanol) is added into the reactor first, and then the pulverized refined cotton fines are put into the reactor for alkalization treatment to obtain alkali cellulose.

[0044] Put 500g of toluene in the etherifier in advance, pump the alkali cellulose into the etherifier, and add 100g of isopropanol. Add 200 g of methyl chloride and 25 g of propylene oxide to the etherifier in turn, and perform etherification reaction at 40° C. for 50 minutes, and then etherification reaction at 90° C. for 50 minutes to obtain a crude HPMC product.

[0045] Add dicumyl peroxide to the crude HPMC product as a cross-linking agent to make ...

Embodiment 3

[0048] 100g of refined cotton is crushed into 0.2-0.4mm fine material with a pulverizer. After evacuating the reactor and using a nitrogen generating device to press nitrogen to replace the air, mix the sodium hydroxide solution (containing 100g of sodium hydroxide) with 1200g of binary organic solvent (made of toluene and isophthalic acid with a mass ratio of 10:1 Propanol) is added into the reactor first, and then the pulverized refined cotton fines are put into the reactor for alkalization treatment to obtain alkali cellulose.

[0049] Put 500g of toluene in the etherifier in advance, pump the alkali cellulose into the etherifier, and add 100g of isopropanol. Add 155g of methyl chloride and 30g of propylene oxide to the etherifier successively, and perform etherification reaction at 50°C for 40 minutes, and then etherification reaction at 70°C for 40 minutes to obtain crude HPMC product.

[0050] Add dicumyl peroxide to the crude HPMC product as a cross-linking agent to ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Viscosityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a method for synthesizing hydroxypropyl methyl cellulose. A nitrogen protected alkalization method and a low and high temperature substep etherification method are employed to prepare hydroxypropyl methyl cellulose with high viscosity. The hydroxypropyl methyl cellulose synthesized by the method provided by the invention has the advantages of good dispersibility in cold water, high viscosity and good thickening water retention capacity, is suitable for production of glue for building, and can be used in wall building, plastering, whitewashing and caulking; meanwhile, the hydroxypropyl methyl cellulose is also applicable to dry-mixed mortar.

Description

technical field [0001] The invention relates to the synthesis of cellulose mixed ethers in the chemical industry, in particular to a synthesis method of hydroxypropyl methylcellulose. Background technique [0002] Hydroxypropyl Methyl Cellulose (Hydroxy Propyl Methyl Cellulose, HPMC) is a cellulose mixed ether variety whose output, usage and quality have been increasing rapidly in recent years. It is made of cotton, wood, propylene oxide and methyl chloride ether. Non-ionic cellulose mixed ether made by chemical process. HPMC has good dispersing, emulsifying, thickening, bonding, water-retaining and gel-retaining properties. It is soluble in water, and can also be dissolved in ethanol and acetone below 70%. HPMC with a special structure can also be directly soluble in ethanol. HPMC can be widely used as film coating, slow-release agent and binder of pharmaceutical preparations, and can also be widely used in petrochemical, building materials, ceramics, textiles, food, daily...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08B11/193
Inventor 费玉元费锦华
Owner 美信佳中维药业股份有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com