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Method for improving water solubility of nanomaterial through surface modification and nanomaterial modified by method

A nanomaterial and surface modification technology, applied in the field of nanomaterials, can solve the problems of high toxicity of polymers, expensive polymers, and easy aggregation of particles, and achieve the effect of low cytotoxicity, simple method, and good hydrophilicity

Inactive Publication Date: 2013-10-30
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particles obtained by these coating methods are relatively easy to aggregate in polar solvents and biological buffers, and these polymers are also relatively expensive, and some polymers are more toxic

Method used

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  • Method for improving water solubility of nanomaterial through surface modification and nanomaterial modified by method
  • Method for improving water solubility of nanomaterial through surface modification and nanomaterial modified by method
  • Method for improving water solubility of nanomaterial through surface modification and nanomaterial modified by method

Examples

Experimental program
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Effect test

Embodiment 1

[0039] Weigh up 3 mg of up-converting fluorescent nanoparticles and add it into 2 mL of cyclohexane to prepare a solution of up-converting fluorescent nanoparticles. Then sonicate for 20 minutes until the up-converting fluorescent nanoparticles are completely dissolved in the organic solvent, add 20 μL of Tween-20, and stir at 1250 r / min for 1 h until the Tween-20 is completely dissolved in the organic solvent for up-conversion Nano fluorescent nanoparticle solution. Then put the up-converting fluorescent nanoparticles solution in a water bath, heat and stir, add 10 mL of deionized water, keep the temperature at 70° C. for 4 hours, until the organic solvent evaporates completely, the solution becomes clear and transparent, and the reaction ends. After the reaction, the reaction solution is centrifuged at a speed of 12,000 rpm in a centrifuge, and the up-conversion nanoparticles after centrifugation are washed once with deionized water and dried to collect the powder, which is ...

Embodiment 2

[0041] Weigh 5 mg of up-converting fluorescent nanoparticles and add it into 3 mL of cyclohexane to prepare a solution of up-converting fluorescent nanoparticles. Then sonicate for 30 minutes until the upconverting fluorescent nanoparticles are completely dissolved in the organic solvent, add 50 μL of Tween-40, and stir at 1700 r / min for 2 hours until the Tween-40 is completely dissolved in the organic solvent to obtain upconverting nanoparticles. Fluorescent Nanoparticle Solution. Then put the up-converting nano fluorescent nanoparticle solution in a water bath, heat and stir, add 8mL of phosphate buffer solution with a concentration of 0.01mol / L, keep the temperature at 40°C for 5 hours, until the organic solvent is volatilized and the solution is clear and transparent , the reaction ends. After the reaction, the reaction solution is centrifuged at a speed of 10,000 rpm in a centrifuge, and the centrifuged up-conversion nanoparticles are washed once with deionized water and...

Embodiment 3

[0043] Weigh 5 mg of up-converting fluorescent nanoparticles and add it into 10 mL of cyclohexane to prepare an up-converting fluorescent nanoparticles solution. Then sonicate for 25 minutes until the upconversion fluorescent nanoparticles are completely dissolved in the organic solvent, add 30 μL of Tween-60, and stir at 2400r / min for 2h until the Tween-60 is completely dissolved in the organic solvent to obtain the upconversion nanoparticle. Fluorescent Nanoparticle Solution. Then put the up-conversion nano fluorescent nanoparticle solution in a water bath, heat and stir, add 12mL of distilled water, keep the temperature at 80°C for 3 hours, until the organic solvent evaporates completely, the solution is clear and transparent, and the reaction ends. After the reaction, the reaction solution was centrifuged at a speed of 11,000 rpm in a centrifuge, and the centrifuged up-conversion nanoparticles were washed once with distilled water and then dried, and the powder was collect...

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PUM

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Abstract

The invention relates to a nanomaterial and particularly discloses a method for improving the water solubility of the nanomaterial through surface modification. The method comprises the following steps of: (1) dissolving the nanomaterial in an organic solvent to prepare a solution A; (b) adding a tween-series surfactant into the solution A, stirring to dissolve, adding a water or saline solution, and reacting for 3-5 hours at 40-80 DEG C; and (c) carrying out centrifugal separation on the solution obtained in the step (b) to obtain a solid, washing the solid by using water, and then drying the solid. The nanomaterial modified by the modification method disclosed by the invention has the advantages of good water solubility and low toxicity. Therefore, the nanomaterial can be potentially and widely applied to the fields of bio-labeling, biological detection, biological imaging, treatment of diseases and the like.

Description

technical field [0001] The invention relates to nanomaterials, in particular to a method for improving the water solubility of nanomaterials through surface modification and the nanomaterials modified by the method. Background technique [0002] Rare earth luminescent nanomaterials have many excellent properties and a wide range of uses. Its optical properties are mainly derived from the partial forbidden transition of electrons inside the 4f shell. Its emission spectrum is linear, with long luminous life, high temperature resistance, and high excitation energy. Density, high lumen equivalent characteristics. In addition, rare earth luminescent materials have the advantages of high luminous brightness, long afterglow time, adjustable emission wavelength, no radiation and no pollution that other luminescent materials do not have. It has been widely used in imaging phosphors, computer monitors, nuclear physics, radiation fields and military affairs. Due to the excellent prop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/85C09C3/10C09C1/24B82Y30/00B82Y40/00
Inventor 谷战军任文璐赵宇亮
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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