Method for preparing high-viscosity chitosan quick hemostatic patch
A chitosan, high-viscosity technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limitation, reduced mechanical strength, slow hemostasis, etc., to achieve the effect of strengthening hemostasis and mechanical strength, and controlling the amount of bleeding
Inactive Publication Date: 2013-11-13
黄耀江 +2
5 Cites 7 Cited by
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The invention discloses a method for preparing a high-viscosity chitosan quick hemostatic patch. The method comprises the following steps: preparing chitosan gel from high-viscosity chitosan having a deacetylation degree in the range from 80% to 90%, drying the chitosan gel and then immersing one single side of the chitosan gel into a mixed solution of chloroacetic acid and isopropanol for carboxymethylation, and then soaking the chitosan gel into a 30% glycerol solution for 30 minutes and then draining; and finally, carrying out a cross-linking reaction by using a calcium chloride solution so as to introduce calcium ions and thrombin, and then carrying out vacuum freeze-drying, thereby obtaining the high-viscosity chitosan quick hemostatic patch. Raw materials used for the process of the method are low in cost; the process is simple and convenient, and short in period; the obtained chitosan hemostatic patch is high in adhesiveness, and capable of quickly stopping bleeding of a wound under the promotion effect of the calcium ions and the thrombin.
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Property | Measurement | Unit |
Viscosity | 600.0 ~ 2000.0 | mPa·s |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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