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Method for preparing high-viscosity chitosan quick hemostatic patch

A chitosan, high-viscosity technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limitation, reduced mechanical strength, slow hemostasis, etc., to achieve the effect of strengthening hemostasis and mechanical strength, and controlling the amount of bleeding

Inactive Publication Date: 2013-11-13
黄耀江 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The preparation of this kind of chitosan hemostatic material mainly enhances plasticity and swelling by adding plasticizers and chemical modification of some chitosan, but for wounds with large bleeding volume, its adhesion is poor and hemostasis is slow. Moreover, the mechanical strength decreases after absorption, and the application is limited to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 4g chitosan, the degree of deacetylation is 80%, the viscosity is 2000mPa s, and the viscosity-average molecular weight is 3.8×10 6 , add 200mL of 2% acetic acid solution, stir at room temperature (20-25°C) until completely dissolved, prepare a 2% chitosan solution, let it stand for defoaming, and then filter to obtain a clear chitosan solution, which is baked at 70°C Dry 1h, then inject above-mentioned chitosan solution in the petri dish, and put into precipitation solution overnight (precipitation solution is the dehydrated ethanol solution of glycerol concentration 5%, NaOH concentration 0.05%), until chitosan is completely Precipitate to form chitosan gel, wash with deionized water until neutral. Add chloroacetic acid and isopropanol (mass ratio 1:10) to a sealable glass container, heat it to 70°C after alkalization, put the previously obtained chitosan gel in and react for 30 minutes, take it out, and use a sufficient amount of ethanol Repeated washing many t...

Embodiment 2

[0024] Take 4g chitosan, the degree of deacetylation is 90%, the viscosity is 600mPa s, and the viscosity-average molecular weight is 3.0×10 6 , add 200mL of 2% acetic acid solution, stir at room temperature (20-25°C) until completely dissolved, prepare a 2% chitosan solution, let it stand for defoaming, and then filter to obtain a clear chitosan solution, which is baked at 70°C Dry 1h, then inject above-mentioned chitosan solution in the petri dish, and put into precipitation solution overnight (precipitation solution is the dehydrated ethanol solution of glycerol concentration 5%, NaOH concentration 0.05%), until chitosan is completely Precipitate to form chitosan gel, wash with deionized water until neutral. Add chloroacetic acid and isopropanol (mass ratio 1:10) to a sealable glass container, heat it to 70°C after alkalization, put the previously obtained chitosan gel in and react for 30 minutes, take it out, and use a sufficient amount of ethanol Repeated washing many ti...

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Abstract

The invention discloses a method for preparing a high-viscosity chitosan quick hemostatic patch. The method comprises the following steps: preparing chitosan gel from high-viscosity chitosan having a deacetylation degree in the range from 80% to 90%, drying the chitosan gel and then immersing one single side of the chitosan gel into a mixed solution of chloroacetic acid and isopropanol for carboxymethylation, and then soaking the chitosan gel into a 30% glycerol solution for 30 minutes and then draining; and finally, carrying out a cross-linking reaction by using a calcium chloride solution so as to introduce calcium ions and thrombin, and then carrying out vacuum freeze-drying, thereby obtaining the high-viscosity chitosan quick hemostatic patch. Raw materials used for the process of the method are low in cost; the process is simple and convenient, and short in period; the obtained chitosan hemostatic patch is high in adhesiveness, and capable of quickly stopping bleeding of a wound under the promotion effect of the calcium ions and the thrombin.

Description

Technical field [0001] The invention relates to a method for preparing a high-viscosity chitosan rapid hemostatic patch for medical use, in particular to a production method of a high-viscosity chitosan hemostatic patch for rapid wound hemostasis through the comprehensive action of various coagulation factors. Background technique [0002] Chitosan has long been found to have various superior properties such as antibacterial, hemostatic, and good tissue compatibility, and has been used as a hemostatic powder, but it has been widely accepted as a hemostatic material in recent years. Chitosan will not affect the activity of protein in the blood due to its alkalinity and similar blood pH value. It should also be emphasized that the coagulation process caused by chitosan does not depend on the coagulation system. Studies have shown that: (1) in heparinization (2) Chitosan can still agglutinate red blood cells after injection of prostacyclin to inhibit platelet function; (3) Chit...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/38A61L15/28A61L15/18A61L15/42
Inventor 黄耀江孙雷蒋丹慕雷张玉玺王进
Owner 黄耀江
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