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New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof

A zwitterionic and polymer technology, applied in the field of zwitterionic polymers, can solve problems such as difficult to find groups and complex surface modification methods, achieve low concentration requirements, excellent anti-bacterial adhesion and surface lubrication, and film-forming fast effect

Active Publication Date: 2013-11-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the strong hydration ability, the surface modification method is very complicated, and it is difficult to find a group with good water solubility, which helps the zwitterionic polymer to be fixed on the surface of the material.

Method used

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  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof
  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof
  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Functionalized self-assembly of titanium oxide surface

[0036] (1) Preparation of polymer

[0037] 1) Using reversible addition-fragmentation chain transfer (RAFT) polymerization method, take a 10mL eggplant-shaped reaction flask with a branch tube and add 4-cyanovaleric acid dithiobenzoic acid, 4,4' -Azobis (4-cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put in a stir bar, and quickly dissolve the solids, seal the reaction flask, and let nitrogen gas flow for 30 minutes under ice bath conditions. The anaerobic reaction system was placed in an oil bath at 60°C to obtain a polymer (named pSBMA). Pay attention to the use of tin foil to avoid light during the entire operation.

[0038] 2) Adopt the condensation and acylation reaction of carboxylic acid and amine, and take 1mL centrifuge tube as the reaction vessel. First, dissolve pSBMA in 2-(N-morpholine) ethanesulfonic a...

Embodiment 2

[0052] Example 2: Functionalized self-assembly of stainless steel surface

[0053] (1) Preparation of polymer

[0054] 1) Using reversible addition-fragmentation chain transfer (RAFT) polymerization method, take a 10mL eggplant-shaped reaction flask with a branch tube and add 4-cyanovaleric acid dithiobenzoic acid, 4,4' -Azobis (4-cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put in a stir bar, and quickly dissolve the solids, seal the reaction flask, and let nitrogen gas flow for 30 minutes under ice bath conditions. The anaerobic reaction system was placed in an oil bath at 60°C to obtain a polymer (named pSBMA). Pay attention to the use of tin foil to avoid light during the entire operation.

[0055] 2) Adopt the condensation and acylation reaction of carboxylic acid and amine, and take 1mL centrifuge tube as the reaction vessel. First, dissolve pSBMA in 2-(N-morpholine) ethanesulfonic ...

Embodiment 3

[0070] Example 3: Fe 3 O 4 Surface modification of magnetic nanoparticles

[0071] (1) Preparation of polymer

[0072] 1) Using reversible addition-fragmentation chain transfer (RAFT) polymerization method, take a 10mL eggplant-shaped reaction flask with a branch tube and add 4-cyanovaleric acid dithiobenzoic acid, 4,4' -Azobis (4-cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put in a stir bar, and quickly dissolve the solids, seal the reaction flask, and let nitrogen gas flow for 30 minutes under ice bath conditions. The anaerobic reaction system was placed in an oil bath at 60°C to obtain a polymer (named pSBMA). Pay attention to the use of tin foil to avoid light during the entire operation.

[0073] 2) Adopt the condensation and acylation reaction of carboxylic acid and amine, and take 1mL centrifuge tube as the reaction vessel. First, dissolve pSBMA in 2-(N-morpholine) ethanesulfonic ...

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Abstract

The invention discloses new zwitter-ionic polymer containing multiple phosphonic acid end groups, a preparation method and an application thereof. The new zwitter-ionic polymer has the structure shown in a formula (I). In the formula (I), n is more than or equal to 10 and less than or equal to 37. The new zwitter-ionic polymer can be used for grafting modification of the metal-oxide surface, so that the modified surface has excellent hydrophilicity, protein adsorbability and bacterium adhesion resistance; and the new zwitter-ionic polymer is especially applicable to fast modification of the surface of the biomedical material containing the metal-oxide surface so as to improve the biocompatibility, bacterium adhesion resistance and surface lubricity of the material.

Description

Technical field [0001] The present invention relates to a zwitterionic polymer containing polyphosphonic acid end groups. Background technique [0002] Biomedical materials refer to materials with special properties and special functions that are used for artificial organs, surgical repair, physical therapy rehabilitation, diagnosis, and treatment of diseases without serious adverse effects on human tissues. Including various synthetic materials and natural polymer materials, metal and alloy materials, ceramics and carbon materials, and various composite materials, the products made of them have been widely used in clinical and scientific research. Among them, inorganic biomedical materials have metal or metal oxide as their surface characteristics, and are widely used in artificial prostheses, stents, surgical instruments and other fields. In order to make inorganic biomedical materials have better biocompatibility, anti-bacterial adhesion ability and surface lubrication abilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/38C08F8/40C08F2/38C08G83/00
Inventor 陈圣福孙灏天张娟王震
Owner ZHEJIANG UNIV
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