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New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof

A zwitterionic and polymer technology, applied in the field of zwitterionic polymers, can solve the problems of complex surface modification methods, difficult to find groups, etc., to achieve excellent anti-bacterial adhesion ability and surface lubrication ability, low concentration requirements, modified layer stabilization effect

Active Publication Date: 2015-05-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of the strong hydration ability, the surface modification method is very complicated, and it is difficult to find a group with good water solubility, which helps the zwitterionic polymer to be fixed on the surface of the material.

Method used

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  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof
  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof
  • New zwitter-ionic polymer containing multiple phosphonic acid end groups, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Functional Self-Assembly of Titanium Oxide Surface

[0036] (1) Preparation of polymer

[0037] 1) Using the reversible addition‐fragmentation chain transfer (RAFT) polymerization method, take a 10 mL eggplant-shaped reaction bottle with a branch tube, add 4‐cyanovaleric acid dithiobenzoic acid, 4,4' ‐Azobis(4‐cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put it into a stirrer, dissolve the solid quickly, seal the reaction bottle, and pass nitrogen gas for 30 minutes under ice bath conditions. The oxygen-free reaction system was placed in an oil bath at 60°C to react to obtain a polymer (named pSBMA). During the whole operation, pay attention to protect from light with tin foil.

[0038] 2) Condensation acylation reaction of carboxylic acid and amine is adopted, and a 1 mL centrifuge tube is used as a reaction vessel. First, pSBMA was dissolved in 2‐(N‐morpholine)e...

Embodiment 2

[0052] Example 2: Functionalized self-assembly of stainless steel surfaces

[0053] (1) Preparation of polymer

[0054] 1) Using the reversible addition‐fragmentation chain transfer (RAFT) polymerization method, take a 10 mL eggplant-shaped reaction bottle with a branch tube, add 4‐cyanovaleric acid dithiobenzoic acid, 4,4' ‐Azobis(4‐cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put it into a stirrer, dissolve the solid quickly, seal the reaction bottle, and pass nitrogen gas for 30 minutes under ice bath conditions. The oxygen-free reaction system was placed in an oil bath at 60°C to react to obtain a polymer (named pSBMA). During the whole operation, pay attention to protect from light with tin foil.

[0055] 2) Condensation acylation reaction of carboxylic acid and amine is adopted, and a 1 mL centrifuge tube is used as a reaction vessel. First, pSBMA was dissolved in 2‐(N‐morpho...

Embodiment 3

[0070] Example 3: Fe 3 o 4 Surface Modification of Magnetic Nanoparticles

[0071] (1) Preparation of polymer

[0072] 1) Using the reversible addition‐fragmentation chain transfer (RAFT) polymerization method, take a 10 mL eggplant-shaped reaction bottle with a branch tube, add 4‐cyanovaleric acid dithiobenzoic acid, 4,4' ‐Azobis(4‐cyanovaleric acid), monomeric thiobetaine methyl acrylate (SBMA). Then add a 10:1 (volume ratio) mixture of methanol and deionized water, put it into a stirrer, dissolve the solid quickly, seal the reaction bottle, and pass nitrogen gas for 30 minutes under ice bath conditions. The oxygen-free reaction system was placed in an oil bath at 60°C to react to obtain a polymer (named pSBMA). During the whole operation, pay attention to protect from light with tin foil.

[0073] 2) Condensation acylation reaction of carboxylic acid and amine is adopted, and a 1 mL centrifuge tube is used as a reaction vessel. First, pSBMA was dissolved in 2‐(N‐morph...

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Abstract

The invention discloses new zwitter-ionic polymer containing multiple phosphonic acid end groups, a preparation method and an application thereof. The new zwitter-ionic polymer has the structure shown in a formula (I). In the formula (I), n is more than or equal to 10 and less than or equal to 37. The new zwitter-ionic polymer can be used for grafting modification of the metal-oxide surface, so that the modified surface has excellent hydrophilicity, protein adsorbability and bacterium adhesion resistance; and the new zwitter-ionic polymer is especially applicable to fast modification of the surface of the biomedical material containing the metal-oxide surface so as to improve the biocompatibility, bacterium adhesion resistance and surface lubricity of the material.

Description

technical field [0001] The present invention relates to a zwitterionic polymer containing polyphosphonic acid end groups. Background technique [0002] Biomedical materials refer to a class of materials with special properties and special functions, which are used for artificial organs, surgical repair, physiotherapy rehabilitation, diagnosis, and treatment of diseases, and do not have serious adverse effects on human tissues. Including various synthetic materials and natural polymer materials, metal and alloy materials, ceramic and carbon materials and various composite materials, the products made of them have been widely used in clinical and scientific research. Among them, inorganic biomedical materials are characterized by metal or metal oxide on the surface, and are widely used in artificial prosthesis, stent, surgical instruments and other fields. In order to make inorganic biomedical materials have better biocompatibility, anti-bacterial adhesion ability and surface...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/38C08F8/40C08F2/38C08G83/00
Inventor 陈圣福孙灏天张娟王震
Owner ZHEJIANG UNIV
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