Preparation method of shuanghuanglian freeze-dried powder for intravenous injection

A technology for intravenous administration of Shuanghuanglian, which is applied in the field of preparation of Shuanghuanglian freeze-dried powder, can solve the problems of high cost, long drying time and low efficiency of Shuanghuanglian freeze-dried powder, and achieves short drying time, rapid sublimation, and reduced The effect of production costs

Inactive Publication Date: 2013-11-27
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems of long drying time, high cost and low efficiency in the preparation of Shuanghuanglian freeze-dried powder by the existing method, and provides a preparation method of Shuanghuanglian freeze-dried powder for intravenous administration

Method used

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specific Embodiment approach 1

[0016] Embodiment 1: A preparation method of Shuanghuanglian freeze-dried powder for intravenous administration according to the present embodiment is carried out according to the following steps:

[0017] 1. Weigh 2 parts of forsythia, 1 part of honeysuckle and 1 part of Scutellaria baicalensis by weight, and set aside;

[0018] 2. a. Decoct the Scutellaria baicalensis weighed in step 1 with water for 2 to 4 times, each time for 0.5 to 1.5 hours, filter, combine the filtrate, adjust the pH value of the filtrate to 1.0 to 2.0, and keep it warm at 75 to 85°C for 15 to 60 minutes , stand at room temperature for 12-24 hours, filter, collect the precipitate, add 6-10 times the weight of the precipitated water, stir evenly, adjust the pH value to 6.0-7.0 to obtain a mixed solution; b, add 0.5-2 times the volume of the mixed solution to the mixed solution 95% ethanol, filter, collect the filtrate, adjust the pH value of the filtrate to 1.5-2.5, keep it at 55-65°C for 15-60min, let i...

specific Embodiment approach 2

[0025] Embodiment 2: This embodiment differs from Embodiment 1 in that: the mass-volume ratio of the activated carbon described in step c to the initial mixture is 0.008-0.01 g: 1 mL. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0026] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the pH value of the filtrate is adjusted to 1.0 as described in step a, and the temperature is kept at 80° C. for 30 minutes. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a preparation method of shuanghuanglian freeze-dried powder for intravenous injection, and aims to solve the problems of long drying time, high cost and low efficiency, which prevail in conventional preparation method of the shuanghuanglian freeze-dried powder. The method comprises the following steps: decocting and filtering forsythia, honeysuckle and scutellaria baicalensis, alcohol washing, water washing, still standing, and obtaining shuanghuanglian extractive; blending the extractive, filtering, carrying out spray freeze drying, and obtaining. Compared with the conventional freeze-drying, the method provided by the invention can reduce more than 50% time, greatly reduce the production cost, and improve the production efficiency. The invention is applied to the field of shuanghuanglian freeze-dried powder preparation.

Description

technical field [0001] The invention relates to a preparation method of Shuanghuanglian freeze-dried powder. Background technique [0002] Shuanghuanglian is made of three traditional Chinese medicines: Shuanghua, Scutellaria, and Forsythia. Among them, Shuanghua is cold in nature, sweet in taste, and fragrant in awn. It can not only cool the wind and warm the heat, but also detoxify the blood. rash, sore throat. Coptis chinensis is bitter and cold in nature, relieves residual fire in the heart, and clears damp heat in the intestines. It is suitable for exuberant heart fire, damp heat in the stomach, and damp heat plague. Forsythia is cool in nature and bitter in taste, clears heart-fire and relieves fire, removes various fevers in the upper burner, and is suitable for the onset of febrile disease, headache, fever, polydipsia, and carbuncle sores, erysipelas, macule, etc. caused by heat-toxin stagnation. According to modern pharmacological research and animal experiments, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/19A61P31/04A61P17/00A61P11/00
Inventor 刘玠颜莉刘秋丽李殿明崔仁海王英新
Owner 哈药集团中药二厂
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